From the artificial to the living bone SYBDNE is an osteoconductive synthetic graft material designed to fill the space of the missing bone and encourage the growth of new bone tissue. SYBDNE is a synthetic bone graft material composed of biocompatible calcium phosphate materials that are similar to bone. Bone grafts must provide similar properties to those of human bone.

Alloplast = Syntetic Origin Composition 99.9%Tricalcium Phosphate ((3-TCP) Function Designed for the filling of bone voids or defects Structure Porosity of granules 90% Pore size 300-500 microns Interconnected Porosity creating open channels Proprieties Biocompatibility Osteoconductive Optimal Resorption Rate Excellent Mechanical Resistance Indications 5YB0NE is intended to be used as a bone void filler or augmentation material for bone defects. Sinus floor elevation Alveolar filling or augmentation Alveolar regeneration Reconstruction of tumor and cyst defects Filling of extraction cavities

ADVANTAGES Security 100% synthetic & 100% resorbable. Total Resorption SYBONE is replaced by new vital bone within 2-6 months. Radiopaque Allows the perfect monitorization of osteointegration. High Cohesiveness and volume conservation SYBONE is very hydrophilic, that confers an excellent cohesivity of particules, which in turn allows the conservation of the volume of the initial cavity. Vascularization SYBONE induces a remarkable vascularization. No Membrane It is not necessary to use membrane, due to SYBONEs physical and mechanical properties.

• SYBONE in the form of granules helps to fill empty irregular spaces. • Impregnate the implant with patient's blood or autologous bone marrow. • SYBONE should have contact with cancellous tissue. • The bone surface must be freshened and slightly bleeding. • The filling must be complete with slight impaction. • The wound closure must be complete and airtight. • The combination of SYBONE with any medical substance during implantation is carried out under the Surgeon's responsibility.

Vial = 1gr (5 vials in the box) ABM-0002 Indicated for small peridontal defects ABM-0003 Indicated for the filling of cysts and the filling of alveolar cavity ABM-0004 Indicated for sinus floor elevation and the filling of large cysts

Case description: Sinus Lift Elevation on a 42 year old patient Treatment: 1g SYBDNE, 0.5-1mm granules Outcome: The expansion of the alveolar ridge and the fracture of the maxillary sinus floor with Summers osteotomes is observed in the first x-ray. The sinus floor was filed with SYBDNE, granules 0.5-1mm mixed with PRP. The implant was then placed after the bone graft.The porosity of the granules of SYBDNE favored the aggregation of fibrin on the surface hindering the formation of air voids that could weaken the graft and promote the proliferation of microorganisms. With a 5 months follow-up...

Case description: Odontogenic Inflammatory Cyst on a 76 year old patient Treatment: 1g 5YB0NE 0.5-1mm granules Outcome: An odontogenic inflammatory cyst on a 76 year old female patient was extracted. The reconstruction of the area was performed with 1g of SYBDNE, 0.5-1mm granules with the aim of leveling the osseous crest of the upper jaw for a better fitting of the immediate loading prosthesis. Monthly follow-ups were performed to monitor the rate of osteointegration and consequently the reduction of the cyst. Radiographic evidence is presented prior to surgery, after surgery and with a 5 month...

Our advanced tissue technology results in improved bioresorbable polymer-based membrane for tissue regeneration. Contact us to find out more about how TAG Dental SYCURE's ongoing research and development in regenerative medicine can help you better serve patients.

tc& T.A.G. Medical Products Corporation Ltd Kibbutz Gaaton 2513000 Israel Tel: +972 (0}4 9858400 www.tag-med.com DA-SYBONE Rev.B