MTHFR
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5,10-methylenetetrahydro-foIate Red uctase Gene 677C / T Polymorphism Assay Kit ⚫ A key enzyme in the metabolism of folate and homocysteine ⚫ The gene encoding MTHFR has polymorphisms at the 677 site, including CC, CT, and TT genotypes. The MTHFR gene is located at position lp36.3 on chromosome 1, with polymorphism at position 677 • Reduce MTHFR enzyme activity • Elevate homocysteine levels • Disrupt the body's coagulation and fibrinolysis systems MTHFR C677T Gene mutation • Decrease folate conversion rate • Hinder process of converting methionine to S-adenosylmethionine • Reduce degree of methylation • Hinder the process of cell mitosis • Reduce MTHFR activity • Reduce production of 5-tetrahydrofolate • Reduce the synthesis and repair of damaged DNA Atherosclerosis increases Coronary heart disease Stroke Other cardiovascular diseases Neural tube malformation Congenital heart disease Cleft lip and palate Down syndrome Other birth defect symptoms

TAILORMED5,10-methylenetetrahydro-foIate Red uctase Gene 677C / T Polymorphism Assay KitMETHODOLOGY PCR-fluorescence probing TARGET GROUPS • Pregnant women • Hypertension patients • Cardiovascular diseases patients • Elderly dementia patients • Depression patients • Parkinson's disease patients (PCR-Fluorescence Probing) ADVANTAGE Accuracy: Multiple population clinical validation, accuracy>99.9%. Fast: no need for routine nucleic acid extraction. No contamination: Enclosed PCR products, avoid contamination. Multiple specifications: 24/48/96 samples/pack, high throughput High specificity:...