PRODUCT BROCHURE Custom-Made Relay® Branch Built to Accommodate For more information, visit terumoaortic.com/relay-branch

Addressing Challenges in the Aortic Arch The Custom-made Relay®Branch provides an effective solution for the treatment of aortic arch disease1. Depending on the pathology and the targeted supra aortic vessel(s), this program can provide: Triple Branch ‫ چ‬The complete endovascular solution for the repair of the aortic arch 2 Double Branch ‫ چ‬Two tunnels to be deployed under the BCT and LCCA 3 Single Branch ‫ چ‬One tunnel to be deployed under the LSA 4 ‫ چ‬The Single Branch Customisation may include a proximal scallop to proximally extend the landing zone 5 Van der Weijde et al. (2019) - ‘Total...

Custom Solutions The Custom-made Relay®Branch builds upon the core features of the standard Relay®Pro platform, incorporating the same advanced technology and design principles, but with added customisation to address a specific patient need. The benefits of this platform include: Graft ► Potential customisation options ► Wide window customisation ► Lock stent technology (where necessary) ► Dual sheath technology ► Pre-curved nitinol inner catheter ► Asymmetrical proximal clasping ► TREO-based limb design ► Proximal clasping and short nose cone delivery system 3. Case images courtesy of Prof....

Potential Customisation Options Tailored Design For Every Need Main Body Internal Tunnels *The Relay Triple Branch and Relay Branch Proximal Scallop with Retrograde tunnel main bodies with 42mm or greater proximal diameter are loaded onto the RelayPlus delivery system. Distal diameter (20 - 48mm) Note: Measurements may vary depending on the specific configuration and the antegrade or retrograde position of the tunnels. Branches Total length (70 - 140mm)

Wide Window Customisation Designed for Easy Cannulation ‫ چ‬The cannulation window is designed to align to the outer curvature of the aorta to help simplify branch cannulation ± 48min Mean Operative Time Including Cervical Bypassing 6 40min Median Fluoroscopy Time 7 The large window [...] makes cannulation easy and fast while maintaining cerebral perfusion  7  Lock Stent Technology* Designed to prevent disconnection ‫ چ‬Dull barbs facing towards lumen of the tunnel designed to prevent potential disconnection of the branches 7 Branch disconnection or migration 7 The presence of rounded barbs...

Dual Sheath Technology and Pre-Curved Nitinol Inner Catheter Navigating the arch with care, designed for self-alignment ‫ چ‬Dual sheath delivery system, to facilitate the atraumatic advancement into zone 0 ‫ چ‬Pre-curved nitinol inner catheter, to align the cannulation window to the outer curvature of the aorta [...]a “self-righting” inner sheath that aligns the large branch cannulation window to the outer curve [...].  8  Stroke rate at 30-day follow-up 9 (1/12) Benchtop Model * Custom-made double branch devices are based on an evolutionary device Terumo Aortic has developed that was part...

Support Wires and Asymmetrical Proximal Clasping Precise and Controlled Deployment ‫ چ‬Two support wires guide the inferior portion toward the inner aortic wall, keeping it aligned with the landing zone, minimising the risk of retroflex ‫ چ‬Two clasped stent apices, both located on the outer curve, allow for precise and controlled deployment The presence of pared “driving-wires” (support wires) allows for a precise proximal landing in Zone 0 and for progressive apposition of the proximal stent-graft segment against the aortic wall. 10  Early Type Ia Endoleak 11 (1/43) Bridge Stents ‫ چ‬TREO-based...

Committed to Aortic Care Discover solutions for every segment of the aorta terumoaortic.com LinkedIn View Custom-Made device IFU at eifu.terumoaortic.com for more information on use, indications, contraindications and warnings/precautions. Custom made devices are specifically made in accordance with a written prescription of any person authorised by national law by virtue of that person’s professional qualifications; which gives (1) specific design characteristics provided under that person’s responsibility and (2) is intended for the sole use of a particular patient exclusively to meet their...