THE POWER OF MASS SPECTROMETRY FOR IC ANALYTICAL CHEMISTS Unleash New Possibilities with Enhanced Detection for IC Applications

THE POWER OF MASS SPECTROMETRY Ion chromatography (IC) excels in analyzing ionic species—analytes of major importance to environmental, food and beverage, pharmaceutical, life science, chemical, power generation, and electronics industries. As the ion chromatography innovator and technology leader for over 40 years, Thermo Fisher Scientific understands what IC analytical chemists need for their work. There is a continuing need for today’s researcher to detect small quantities of analytes in complex samples. But what if you need even lower levels of sensitivity and selectivity to add extra confidence...

IC-MS is a recommended method for sensitive and selective determinations of ions. Combining ion chromatography with MS workflows increases efficiency and sensitivity, and improves resolution in complex samples, leading to more accurate quantitation, improved confidence, and more chemical information about every sample. Thermo Fisher Scientific offers several different mass spectrometer options for IC systems: • single quadrupole MS • triple quadrupole MS • high resolution-accurate mass (HRAM) hybrid quadrupole-Orbitrap MS As the capabilities of these instruments grow, so does their power to provide...

MORE CONFIDENCE Higher Sensitivity and Accurate Quantitation For routine analyses where single digit parts-per-billion (ppb) sensitivities are required, a simple mass detector, such as a single quadrupole mass spectrometer, offers the required sensitivity. Mass detection adds confidence to your quantitation, enabling you to obtain limits of detection (LODs) at least an order of magnitude greater than those provided by conductivity detection. With the use of very specific MS selected ion monitoring (SIM) detection, ppb-level quantification can be performed with greater confidence on a wide range...

Peak Confirmation In addition to the enhanced detection, if your study requires peak confirmation or peak purity analysis the single quadrupole MS detector such as the Thermo Scientific™ ISQ™ EC mass spectrometer will provide complementary molecular weight data, for an increased degree of confidence. AN151 conditions, IonPac AS20 column, 100 µL injection, without desolvation solvent 1700 Apex 101 perchlorate Scan: #2202 RT:... % Suppressed Conductivity Determination of perchlorate in a Municipal Drinking Water Sample. (A) The conductivity channel provides very limited sensitivity towards the...

FLEXIBLE IC-MS COMBINATIONS Thermo Fisher Scientific offers two different IC systems, the Thermo Scientific™ Dionex™ ICS-6000 HPIC™ system and the Thermo Scientific™ Dionex™ Integrion™ HPIC™ system, suited for pairing with MS detection. Each of these unique IC systems can be used with a variety of mass spectrometers, offering increasing levels of confidence, peak confirmation, and structural elucidation for your analyses. Dionex ICS-6000 HPIC system: Dionex Integrion HPIC system Thermo Scientific™ ISQ™ EC A modular, highly flexible IC A compact, integrated IC system Single Quadrupole Mass system...

Mass Spectrometer Quadrupole Triple Quadrupole Triple Quadrupole Selected reaction monitoring (SRM) Orbitrap mass analyzer High Resolution Accurate Mass (HRAM) Orbitrap mass analyzer High Resolution Accurate Mass (HRAM) Structural Elucidation Selected reaction monitoring (SRM) Peak Confirmation Thermo Scientific™ TSQ Altis™ Thermo Scientific™ Q Exactive™ Thermo Scientific™ Orbitrap Fusion™ Hybrid Quadrupole-Orbitrap Mass Mass Spectrometer: An instrument Quantis Triple Quadrupole Spectrometer: High-resolution, accurate- combining the best of quadrupole, ion trap Mass Spectrometers: Best-in- mass...

RESOLVING COMPLEXITY Increased Selectivity for Complex Samples When you need increased sensitivity and peak confirmation, the increased power of a triple quadrupole MS may be the answer. The sensitivity and selectivity of MS/MS detection makes it a highly preferred method for complex sample matrices. For example, perchlorate in baby formula can be quantified, without enrichment at low parts-per-trillion (ppt) levels using simple sample preparation and a TSQ Altis triple quadrupole mass spectrometer for detection. This system provides excellent reproducibility, accuracy, and precision. 100 Infant...

Combining ion chromatography with mass spectrometric detection offers great selectivity. In the example to the right, organic acids were analyzed by IC-MS. Using MS detection, each of these organic acids was observed as a single peak. By overlaying the individual responses for each recorded mass, it is possible to determine how the co-eluting organic acids contribute to the total chromatographic peak. Selectivity for Co-Eluting Peaks Animal feed Sample Determination of organic acids in Animal Feed by single quadrupole IC-MS. (A) The conductivity channel provides sufficient response for the organic...

Structural Elucidation Capabilities IC-MS Analysis Software IC combined with high-resolution, accurate-mass (HRAM) Orbitrap mass spectrometry is an ideal solution for component identification in non-targeted and unknown workflows. For example, identification of lithium-ion battery failure analysis products using HRAM MS/MS offers four-decimal-point accuracy to distinguish between species. The unique fragmentation signature enhances that confidence. In addition to validating a proposed degradation pathway, confidence in the results avoids spending research time and resources going in an unproductive...