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- Q Exactive Plus Orbitrap LC-MS/MS System
Q Exactive Plus Orbitrap LC-MS/MS System
Q Exactive Plus Orbitrap LC-MS/MS System
The Thermo Scientific Q Exactive Plus Orbitrap LC-MS/MS System is an advanced mass spectrometer designed for precise quantification and characterization of proteins and small molecules. It builds on the concept of Quanfirmation, which combines characterization, quantification, and confirmation in a single instrument.
Key Features
- Advanced Quadrupole Technology (AQT): Enhances precursor selection and transmission, improving quantitation of low-abundance analytes in complex matrices.
- Data-Independent Acquisition (DIA) and Parallel Reaction Monitoring (PRM): Provide reproducible quantitation with qualitative confidence.
- Advanced Active Beam Guide (AABG): Reduces noise and extends maintenance intervals.
- Intact Protein Mode: Offers superior trapping of large molecules for improved analysis of intact proteins and protein complexes.
- Enhanced Resolution: Ensures maximum identification confidence in top-down proteomics and lipidomics.
Applications
- Protein Identification: The system identifies significantly more proteins, especially at lower sample amounts, with increased sensitivity and precision.
- Characterization of Intact Proteins: Essential for biotherapeutics development, the system analyzes intact proteins and resolves subunits up to 50 kDa with high sensitivity.
- Quantification: Targeted quantitation is enhanced by high-resolution accurate-mass data, with PRM and HR/AM-SIM providing superior sensitivity and selectivity.
- Data-Independent Acquisition: Offers a high-throughput method for comprehensive protein quantification without requiring detailed sample knowledge beforehand.
Conclusion
The Q Exactive Plus system is a versatile tool for proteomics and pharmaceutical development, offering advanced features for confident and precise analysis of proteins and small molecules.
Catalog excerpts
Thermo Scientific Q Exactive Plus Orbitrap LC-MS/MS System Quanfirmation Plus Characterize • Quantify • Confir
Open the catalog to page 1
Quanfirmation Plus \,kwän-f r-'mä-shan pl s\ 1 : the ability to confidently and routinely characterize, quantify, and confirm using a single mass spectrometer: syn Q Exactive Plus mass spectrometer The Thermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap mass spectrometer introduced the revolutionary concept of Quanfirmation™. The Thermo Scientific Q Exactive Plus takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies. Advanced Active Beam...
Open the catalog to page 2
Analyze single proteins and complex protein mixtures The Q Exactive Plus mass spectrometer facilitates a wide range of protein analysis applications, from antibody characterization to cell- or tissue-based proteomics to targeted or DIA-based protein quantitation. Protein identification, is a fundamental research task. The Q Exactive Plus mass spectrometer delivers increased sensitivity and precision for protein identification. The advanced active beam guide and advanced quadrupole technology improve identification of low-abundance proteins in complex matrices while providing the utmost reliability...
Open the catalog to page 3
Quantify with the highest confidence Targeted quantitation with added confidence Q Exactive Plus transmission gain m/z 74 Q Exactive Plus transmission gain m/z 195 Q Exactive Plus transmission gain m/z 524 Q Exactive Plus transmission gain m/z 1622 Reference Transmission Gain Targeted quantitation is an essential tool for proteomics, pharmaceutical development, and many other fields. The Q Exactive Plus instrument delivers the sensitivity expected from targeted quantitation with the extra measure of analytical confidence provided by high-resolution accurate-mass data. Parallel reaction monitoring...
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