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Thermo Scientific
Q Exactive Plus

Q Exactive Plus

Product catalog summary

Introduction
The Thermo Scientific Q Exactive Plus Orbitrap LC-MS/MS System is an advanced mass spectrometer designed for precise quantification and characterization of proteins and small molecules. It builds on the concept of Quanfirmation, which combines characterization, quantification, and confirmation in a single instrument.

Key Features

Advanced Quadrupole Technology (AQT): Enhances precursor selection and transmission, improving quantitation of low-abundance analytes in complex matrices.
Data-Independent Acquisition (DIA) and Parallel Reaction Monitoring (PRM): Provide reproducible quantitation with qualitative confidence.
Advanced Active Beam Guide (AABG): Reduces noise and extends maintenance intervals.
Intact Protein Mode: Offers superior trapping of large molecules for improved analysis of intact proteins and protein complexes.
Enhanced Resolution: Ensures maximum identification confidence in top-down proteomics and lipidomics.

Protein Identification and Characterization
The Q Exactive Plus system significantly improves protein identification, especially for low-abundance proteins in complex matrices. It offers increased sensitivity and precision, making it ideal for analyzing therapeutic proteins and monoclonal antibodies. The system can resolve subunits as large as 50 kDa with high sensitivity.

Quantification Capabilities
The system excels in targeted quantitation, providing high-resolution accurate-mass data for peptides and small molecules. It employs PRM and HR/AM-SIM for superior sensitivity and selectivity. The AQT enhances ion transmission, increasing quantitative sensitivity.

Data-Independent Acquisition (DIA)
DIA offers a high-throughput method for comprehensive protein quantification with qualitative confirmation. The Q Exactive Plus system's optimized DIA methods and Thermo Scientific Pinpoint software enhance coverage and reproducibility.

Conclusion
The Thermo Scientific Q Exactive Plus Orbitrap LC-MS/MS System is a versatile and powerful tool for proteomics and pharmaceutical development, offering advanced features for confident and precise analysis of proteins and small molecules.

Catalog excerpts

Thermo Scientific Q Exactive Plus Orbitrap LC-MS/MS System Quanfirmation Plus Characterize • Quantify • Confir

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Quanfirmation Plus \,kwän-f r-'mä-shan pl s\ 1 : the ability to confidently and routinely characterize, quantify, and confirm using a single mass spectrometer: syn Q Exactive Plus mass spectrometer The Thermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap mass spectrometer introduced the revolutionary concept of Quanfirmation™. The Thermo Scientific Q Exactive Plus takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies. Advanced Active Beam...

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Analyze single proteins and complex protein mixtures The Q Exactive Plus mass spectrometer facilitates a wide range of protein analysis applications, from antibody characterization to cell- or tissue-based proteomics to targeted or DIA-based protein quantitation. Protein identification, is a fundamental research task. The Q Exactive Plus mass spectrometer delivers increased sensitivity and precision for protein identification. The advanced active beam guide and advanced quadrupole technology improve identification of low-abundance proteins in complex matrices while providing the utmost reliability...

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Quantify with the highest confidence Targeted quantitation with added confidence Q Exactive Plus transmission gain m/z 74 Q Exactive Plus transmission gain m/z 195 Q Exactive Plus transmission gain m/z 524 Q Exactive Plus transmission gain m/z 1622 Reference Transmission Gain Targeted quantitation is an essential tool for proteomics, pharmaceutical development, and many other fields. The Q Exactive Plus instrument delivers the sensitivity expected from targeted quantitation with the extra measure of analytical confidence provided by high-resolution accurate-mass data. Parallel reaction monitoring...

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