New PMMA Membrane for Better Quality of Life Hollow Fiber Dialyzer

New Membrane Structure by “Sophisticated Pore Controlling Technology” “FILTRYZER” is made with Polymethylmethacrylate (PMMA) membrane and TORAY is the only manufacturer which succeeded in developing it as a dialysis membrane. FILTRYZER was introduced in 1977 and it has enjoyed a good reputation all over the world due to its excellent biocompatibility, high removal performance, wide range of UFR, and unique adsorption characteristics for various proteins. The membrane consists of 2 kinds of polymers, isotactic PMMA (iso-PMMA) and syndiotactic PMMA (syn-PMMA). These polymers form the stereocomplex...

Structure of new PMMA membrane BG Pore structure As shown in the figure, BG membrane is designed by homogenizing the pore size and increasing the number of pores, resulting in the improvement of the removal through small molecules to low molecular weight proteins such as β2-MG. Improved diffusive permeability (KoA) As for several KoAs (the product of overall mass transfer coefficient and area) for small molecules, Filtryzer BG-U has an improved performance compared with the other types of high-flux PMMA membranes, BK-U and BK-P. Internal data

Proven Biocompatibility Excellent biocompatibility The time course of complement fragment C3a, white blood cell count and platelet count. Touma studied the biocompatibility of BG-U (BG) membrane based upon the time course of complement fragment C3a, WBC count and platelet count in comparison with cellulose tri-acetate membrane, FB, and the previous PMMA membrane, BK-U. As shown by the blue line, the changes on these biocompatibility parameters of BG were more stable than that of FB and almost the same as BK-U. So the biocompatibility of BG membrane is judged to be superior similarly to that of...

Unique Adsorption of Proteins Adsorption of 125I-labeled plasma proteins on the various membranes Using the 6 kinds of dialyzers, Birk et al., conducted the adsorption experiment of plasma protein labeled with radioisotope in vitro. The PMMA membrane showed the maximum amount of protein adsorption per unit surface area. Furthermore, the analysis on the molecular weight of adsorbed proteins revealed that PMMA adsorbed higher molecular weight proteins (HMW proteins) than albumin compared with other membrane materials as shown by the blue bars. When the PMMA membrane was used, the removability by...

Excellent Clinical Benefits to Renal Failure Patients The possibility in decrease of HCV particles in HD patients over hemodialysis therapy In HD patients, the positive rate of anti-HCV antibody seems to be high. However the number of HCV RNA in blood is lower compared to the above rate of antibody. Furthermore, the symptomatic liver failure is not so frequently observed. It may be due to extracorporial treatment through dialyzer use every 2 days. Kuramochi reported that the viral particles decreased in the blood through dialyzer, above all, through PMMA membrane. The viral particles were not...

Technical Data Polystyrene Polymethylmethacrylate Effective surface area (m2) Potting Material Gamma-ray Irradiation Clearance in vitro (mL/min)* Inulin UFR in vitro {mL/hr, at 13.3kPa (100mmHg)}** Max. TMP {kPa (mmHg)} * Clearances are measured with aqueous solution. QB: 200 ±4mL/min, QD: 500 ±10mL/min, QF: 10 ±2mL/min, Temp.: 37 ±1°C ** UFRs are measured data with bovine blood. (Ht 30 ±3%, TP 6.0 ±0.5g/dL) QB: 200 ±4mL/min, TMP: 13.3 ±1.3kPa (100 ±10mmHg), Temp.: 37 ±1°C “Instructions for Use” should be read thoroughly prior to the use of these medical devices. Specifications and designs are...

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