Overview of TORAY FILTRYZER NF Series
The TORAY FILTRYZER NF series is designed to suppress platelet adhesion on membrane surfaces by preventing structural changes in proteins adsorbed on the membrane. This is achieved through a new PMMA membrane that maintains the native structure of proteins, reducing the risk of coagulation during hemodialysis.

Design Concept and Membrane Properties
The PMMA membrane has a unique adsorption property for various proteins, which is crucial in reducing platelet activation and adhesion. The structural integrity of adsorbed proteins, such as albumin, is preserved better on the NF membrane compared to conventional PMMA membranes, as shown by ATR-FTIR spectroscopy.

Improvement in Anti-thrombogenicity
The NF membrane demonstrates lower platelet adhesion and reduced fibrinogen adsorption compared to conventional PMMA membranes. This is evidenced by in vitro studies showing decreased platelet and fibrinogen interaction with the NF membrane.

Protein Adsorption and Membrane Structure
PMMA membranes have a homogeneous structure that acts as both a separating layer and an adsorption site for solutes. They exhibit superior protein adsorption capabilities, adsorbing significantly more proteins than polysulfone membranes.

Clinical Benefits and Specifications
The NF series offers excellent biocompatibility, effectively removing large molecular weight proteins while maintaining a good balance in removing small uremic toxins. The NF-U series is particularly noted for minimizing albumin leakage, making it suitable for patients concerned about malnutrition.

Specifications of NF-U Series
The NF-U series includes various models with different effective surface areas and blood volumes, providing options for different clinical needs. The series offers high clearance rates for substances like urea, creatinine, and phosphate, ensuring efficient dialysis treatment.

Conclusion
The TORAY FILTRYZER NF series represents a significant advancement in hemodialysis technology, offering improved biocompatibility and reduced risk of coagulation through innovative membrane design.