Intranasal Mucosal Atomization Device User Guide Procedure 1 Remove and discard the green vial adapter cap 2 Pierce the medication vial with the syringe vial adapter 6 Using the free hand to hold the occiput of the head stable, place the tip of the MAD Nasal Device snugly against the nostril aiming slightly up and outward (toward the top of the ear) 3 Aspirate the proper volume of medication required to treat the patient (including medication to account for the dead space in the device) Remove (twist off) the syringe from the vial adapter and discard in sharps container 7 Briskly compress the syringe plunger to deliver half of the medication into the nostril Attach the MAD Nasal Device to the syringe via the luer lock connector 8 Move the device over to the opposite nostril and, repeating steps 6 and 7, administer the remaining medication into the nostril if indicated Tips to Improve Success 1. Minimize volume, maximize concentration 2. Maximize total mucosal absorptive surface area 3. Beware of abnormal mucosal characteristics • Use the appropriately concentrated drug • Atomize the drug (rather than drip it in) to cover broad surface area • Mucus, blood and vasoconstrictors may reduce absorption1 • Follow drug manufacturer directions • Use BOTH nostrils to double the absorptive surface area • Suction nostrils or consider alternate drug delivery method in these situations • Aim slightly up and outwards to cover the turbinates and olf

Intranasal Mucosal Atomization Device MAD Nasal™ Device with vial adapter and 1 mL (or 3 mL) syringe MAD Nasal™ Intranasal Mucosal Atomization Device Specifications MAD Nasal Intranasal Mucosal Atomization Device MAD100 MAD Nasal Device with 3 mL Syringe Typical Particle Size MAD Nasal Device with 1 mL Syringe System Dead Space MAD Nasal Device with 1 mL Syringe and Vial Adapter MAD Nasal Device with 3 mL Syringe and Vial Adapter MAD Nasal Device with 3 mL Oral Syringe and Vial Adapter MAD Nasal Device without Syringe To learn more, call us at 866.246.6990 or visit Teleflex.com/MAD *For use with...