Efficient Drug Delivery & Proven Efficacy

- Drug Delivery Specific Balloon Catheter(VesTraveler®): designed specifically fordrugand stent delivery with features of semi-compliant, excellentcrossability and precision balloon expansion. - Special HighBind® Coating Technology: Uniformly 100% surface coating, precision drug loadingand controlled drug release profile. - Evidence-driven of Medicine: minimum drug loss during delivery and controlled release profile during balloon expansion. - Proven Long-last vessel drug retention and efficacy: effective d rug dose remain in vessel upto30days post balloon expansion.

Drug Balloons EverFlowPaclitaxel Coated PTCA Balloon Catheter Uniformly 100% Balloon Surface Coating Proven Long-lastingVessel Drug Retention & Efficacy Precision Drug Loading Contorlled Drug Release: • Better Drug Adhesion • High DrugTransferto Vessel

QCA and Histomorphometric comparison between SeQuent® & EverFlow® in porcine coronary arteries 90days post expansion: there are no significant different. (LA: lumen Area; 1EA: internal Elastic Area; MA: Media Area; NlA: Neointima Area; RFD: vessel referencediameter; MLD: minimal lumen diameter, Lumen loss(%DS)=LLL/MLD postx 100%. (inside Data)).

© EverFlow® Evidence-Driven Device Safety and Efficacy Arterial Drug Concentration Post EverFlow Expansion Coronary Vessel Paclitaxel Residual Dosage: Sufficient and remain up to 35 days post balloon expansion (Paclitaxel safe & efficacy concentration: 0.0085-0.85ug/ml. Axel et al: Circulation.1997; 96:636-645; Sol lot et at; J.Clin.Invest. 1995; 95:1869-1876) EverFlow® PK Data: Paclitaxel (PTX) was detected only within one week in the core organs post balloon expansion, and within safe range (Inside data).

- De novo lesions (primary use in the case of stenosis or occlusion) including small vessels (SVD) - Residual stenosis after balloon or stent PTCA - Pre and post dilatation during coronary stent implantation - Acute or impending vascular occlusion Material required to perform a PTCA balloon catheter procedure: - Rapid Exchange PTCA catheter - Guiding catheter - Inflation syringe with gauge - Introduction lock set with dilator - Contrast medium - Y-connectorwith haemostatic adapter Prior to use, it is essential that all the instruments, catheters and individual components are carefully checked....

o Better everyday o Manufacturer: TT Medical, Inc. Rm. 501, Bldg. l,Songshan Lake National High-Tech Park, Dongguan, Guangdong, E-mail: [email protected] Document No.: TT-PTCA-PCB-BR-EN Rev.1.0 Approval Date: 2025.09.01