© SuperFlow® Balloon Design and Working Principles SuperFlow® Sirolimus-coated Spiral Balloon Catheter is composed by a spiral drug delivery balloon catheter (VesSpiral®) and polymer-free sirolimus coating. Proximal Mypotubc - Spiral Drug Delivery Balloon Catheter(VesSpiral®) :A Non-compliant balloon catheter designed specifically for drug delivery. The balloon surface is integrated with spiral scoring component to dilate vessel under low pressure, prevent slip page during balloon dilation, reduce drug loss during delivery, and enhance drug absorption during balloon dilation. - Polymerfree nano-lipid...

Drug Balloons SuperFlow®Sirolimus Coated Spiral Balloon Catheter LNP Drug Coating Technologies: • Less drug push-loss • Enhanced drug transfer •Sustained, long-lastingdrug release • Precision drug loading

Low drug loss rate during delivery 45% (SCB) vs. 85% (SQP) 2.High drugtransfer rate duringdilation SCB (1.20%) > SQP (0.79%) Slow and controlled drug release in vivo: sustained release within 21 days, no significant difference from SQP 3. Controlled and sustained in-vivo drug release Sustained release in 21 days, no significant difference with SQP SCB: SuperFlow® Sirolimus coated spiral balloon catheter SQP: SeQuent® Please Paclitaxel eluting balloon catheter MA: ACE marked Sirolimus coated balloon catheter

Follow-up Intra-op SCB: SuperFlow® Sirolimus coated spiral balloon catheter; SQP: SeQuent® Please Paclitaxel eluting balloon catheter

* SCB: SuperFlow® Sirolimus coated spiral balloon catheter * SQP: SeQuent® Please Paclitaxel eluting balloon catheter

Order Information SuperFlow® Sirolimus Coated Spiral Balloon Catheter Order Information CAUTION: The law restricts these devices to sale by or on the order of a physician. Indications, contraindications, warnings and instructions for use can befound in the product labelingsupplied with each device. SuperFlow® is a trademark or registered trademark of TT Medical. All cited trademarks are the property of their respective owners.

o Better everyday o Manufacturer: TT Medical, Inc. Rm. 501, Bldg. l,Songshan Lake National High-Tech Park, Dongguan, Guangdong, E-mail: [email protected] Document No.: TT-PTCA-SCB-BR-EN Rev.1.0 Approval Date: 2025.09.01