The premium tool for hypertension and cardiovascular care SupraSystolic Oscillometry • central BP and brachial BP in less than 60s • central pulse pressure wave analysis • accurate, non-invasive and operator independent • direct physics based algorithm • easy to use, familiar with no training required • affordable standalone device Central blood pressure (cBP) is a more accurate marker of cardiovascular risk and outcomes, and a more appropriate target for interventions. A better way to measure blood pressure Raising the standard of care to personalized assessment and treatment SupraSystolic Oscillometric Technology High quality signal acquisition and detailed analysis of the pulse pressure waveform • BP+ measures cBP by briefly holding the cuff 30mmHg above the measured systolic pressure, eliminating sub systolic noise to achieve excellent reproducibility and accuracy • BP+ uses a 1st principles model of the arterial system to reconstruct the entire central BP waveform and calculate the systolic and diastolic central BP Artery occluded by SupraSystolic pressure 1 Pressure in the aorta is generated by the heart 2 Pressure waves travel to the end of the artery and are transferred to the cuff 3 Cuff pressure is measured by BP+

Direct central pressure waveform Accurate central BP waveform measurement without invasive catheters 110 What to look for in a premium central BP and pulse wave analysis tool SupraSystolic technology Pulse wave analysis is most accurate when the measurement is unaffected by radial-ulnar and peripheral circulatory variations Direct assessment BP+ uses physics-based models, not cohort average transfer functions, or empirical statistical regressions that only apply to an “average” patient Realistic entire waveforms BP+ waveforms show clear dicrotic notches and other morphologic features Aortic systolic,...