HPV, STI & TUBERCULOSIS VEIL DEVICES for professionals Oral Veil sampling Anal Veil sampling Swab Veil sampling Veil Brush Patents pending

VEIL TECHNOLOGY FOR ALL ✓ Vaginal self-sampling device ✓ Oral collections of oropharyngeal secretions ✓ Anal self-collection and collection device ✓ Penile self-collection device ✓ Veil Swab and Cytologic Veil brush for clinicians For orders, please send your inquiry at contact@v

ALL RANGE PRODUCTS We provide the solution, you get the best results Oral Veil Device UP2 RetrofitterTM Tube for standard swab of 80mm Breakable creasing Veil swab Veil Brush for Cytology Anal Veil Device Vaginal Veil Device Penile Veil Device Economic micro automation assay For orders, please send your inquiry at [email protected]

V-VEIL UP2TM Vaginal Veil Vaginal Veil The self-sampling vaginal veil V-Veil UP2TM is a class I, non-sterile, UVC disinfected medical device, for the collection of secretions, various fluids and substances from the human vaginal cavity and cervix, for diagnosis by laboratory tests. POSSIBLE ANALYSES with V-VEIL UP2TM HPV genotyping Vaginal Microbiome Chlamydia trachomatis • Trichomonas vaginalis • Gardnerella vaginalis Neisseria gonorrhoeae Ureaplasma parvum/ • Herpes Simplex virus 1 • Herpes Simplex virus 2 Ureaplasma urealyticum Mycoplasma Genitalium • Syphilis (Treponema pallidum) Mycoplasma...

V-VEIL UP2TM Vaginal KITS V-Veil UP2TM KIT 4.3 14mm Self-Sampling Veil Vaginal Veil V-Veil UP2TM KIT 1.3 14mm Self-Sampling Veil V-VEIL UP2TM KITS are self-sampling procedure packs used to collect secretions, various fluids and substances from the vaginal cavity and cervix, for diagnosis by laboratory tests. ü Self-Sampling Medical Device CLASS I according to Regulation (EU) 2017/745 (CE mark under the responsibility of the manufacturer). ü Produced in EN ISO 13485:2016 certified facility, in ISO 8 clean rooms. ü V-Veil UP2TM is listed as medical device for self-sampling into technology landscape...

ORAL VEIL DEVICE V-Veil UP2TM Oral Kit ü Collection of oropharyngeal secretions through deep expectoration ü HPV, STI and Tuberculosis detection ü Veil efficiency: +20% of DNA release Oral Veil ü Compatible with UP2 RetrofitterTM tube For orders, please send your inquiry at [email protected]

ANAL VEIL DEVICE V-Veil UP2TM Anal Kit ü Self-sampling for women and men, including MSM ü Veil efficiency: +20% of DNA release ü Technology available for self-sampling and clinician collection ü Anatomic curve design and creasing Veil shape for optimal collection ü Available with cap or with pierceable aluminum foil HOW TO USE For orders, please send your inquiry at [email protected] Anal Veil ü 96% satisfaction with anal Veil and 94% usabil

PENILE VEIL DEVICE V-Veil UP2TM Penile Kit ü Collect safely from urethra and the skin of the penis for detection of HPV and STI Penile Veil ü Veil efficiency: +20% of DNA release ü Technology available for self-sampling and clinician collection ü Compatible with UP2 RetrofitterTM tube ü Available with cap or with pierceable aluminum foil For orders, please send your inquiry at [email protected]

BREAKABLE CREASING VEIL SWAB V-Veil UP2TM Swab ü Creasing Veil shape to optimize collection ü Contact surface is 6 times bigger than a standard swab ü Curved and asymmetrical rotation ü Designed to adapt at any uterine anatomy ü Veil efficiency: +20% of DNA release ü Can be used directly with automation assay ü Compatible with UP2 RetrofitterTM tube For orders, please send your inquiry at [email protected] Veil Swab ü Different angles of the swab pos

VEIL BRUSH FOR CYTOLOGY V-Veil UP2TM Brush ü Combination of Brush and Veil ü Curved and asymmetrical rotation, Ø32mm ü Different angles of the brush possible Veil Brush ü Designed to adapt at any uterine anatomy ü Creasing veil shape to optimize the collection ü The Veil brush doesn’t float in the tube ü ü No oxidation of the Cells, Better for RNA For orders, please send your inquiry at contact

ECONOMIC MICRO AUTOMATION ASSAY *Compatible with ü Original rack of 24 tubes (for 14-16ml) ü Original rack of 16 tubes rack (for 14-16ml) For orders, please send your inquiry at [email protected]

Next-generation primary tube, with UP2 Retrofitter™, allows laboratories to use the primary tube, containing the self-collected device, directly with a preanalytical robot, without the need for an intermediate tube and barcode. The patented technology V-Veil UP2™ with UP2 Retrofitter™, is suitable for all clinics, hospitals and laboratories, as it offers: • Efficiency • Neutrality with respect to molecular biology reagents • Compatibility with all HPV PCR Kits available on the market • Compatible with 80mm standard breakable ü swab Size compatible with frozen storage boxes +32oC LABORATORY ADVANTAGES...

UP2 RETROFITTERTM TUBE HOW IT WORKS LABORATORY STEPS Once the laboratory receives the UP2 RetrofitterTM Tube, with the collected sample, the laboratory technician performs the following steps: 2. Add 5 ml of any of the PCRcompatible, reaction interference-free elution media, that can be: ü Reaction interference-free aqueous buffered collection medium ü Tris-EDTA (TE) buffer (1X) pH 8.0 for molecular biology ü Phosphate-buffered saline (“PBS”) ü Physiological saline solution ü Universal Transport Medium 3 ü Viral Transport Medium ü Usual cytological medium for HPV such as methanol-based or ethanol-based...

V-VEIL UP2TM STUDY IN GENERAL 253 FEMALE POPULATION A prospective randomized non-inferiority trial This study was performed on 253 adult women by the research team of the Laboratory of Virology of the Hospital Georges Pompidou in France. The graphic below compares the molecular detection of HPV genotypes performed from: Genital secretions self-collected by women themselves, using the V-Veil UP2TM Genital secretions collected by a gynaecologist or a nurse, using a standard swab Comparison of effectiveness between two methods Women number Vaginal Veil Collector V-VEIL UP2 Endocervical Flocked Swab...