Real-time Motion Tracking for Real-Life Results GPS FOR THE BODY TRACKING Objective approach to radiation delivery. Prostate location information is displayed in an intuitive graphical format, facilitating objective, rapid interpretation of prostate movement on the lateral, longitudinal, and vertical axes. Therapists can respond to target motion at any point, using data to make objective decisions about when to intervene and hold the beam. Prostate motion is variable and unpredictable, posing challenges while delivering external beam radiation therapy to treat prostate cancer. As a clinician, if you could see and track target motion in real time during treatment delivery, you could confidently reduce the margins between the clinical target volume (CTV) and the planning target volume (PTV). The Calypso® System by Varian provides that capability. Using GPS for the Body® Technology, Calypso detects even slight movement of the target, so you can keep it in the path of Varian’s precise radiation beam. Tighter treatment margins can help you reduce potential side effects and improve the quality of life for your patients, escalate dose to improve disease control, or accelerate treatments with SBRT. Using real-time tracking and real-time treatments, Calypso can reduce treatment margins resulting in reduced side effects1, even with increased dose. for Health Professionals Only The advanced motion management option automates this response to organ motion with a continuous, real-time signal. Radiation delivery pauses when the target moves outside the clinician-defined threshold. Radiation delivery resumes when the target is back within the threshold. No additional ionizing radiation. Calypso tracks the target using radiofrequency waves, an innovation referred to as GPS for the Body technology. Three electromagnetic transponders implanted during a simple outpatient procedure, transmit location information about the target. The tracking system locks onto the signal during patient setup and tracks it throughout the treatment. Sandler, Howard, et al. “Reduction in Patient-reported Acute Morbidity in Prostate Cancer Patients Treated With 81 Gy Intensity-modulated Radiotherapy Using Reduced Planning Target Volume Margins and Electromagnetic Tracking: Assessing the Impact of Margin Reduction Study.” Urology 75 no. 5, (2010): 1004–1008.

PROSTATE SBRT Hypofractionated, high-dose prostate treatments have shown promising results for some patients2. When escalating dose, you need the confidence that real-time motion tracking provides. The Calypso system enables your clinic to offer SBRT prostate treatment, with its advantages. • Accelerated treatment • More concentrated dose • Reduced CTV-to-PTV margins • Reduced treatment-related side effects SOLUTION COMPONENTS Calypso System • Electromagnetic Beacon® transponder implants • 4D electromagnetic array • Optical system with 3 infrared cameras • 4D tracking station • 4D Console Qfix™...