GAMMAMEDPLUS iX, 3/24 iX AFTERLOADERS FEATURE SHEET The GammaMedplus™ iX HDR/PDR afterloader with its iX control software offers compatibility with hospital networks and enhances the high dose rate (HDR) and pulse dose rate (PDR) brachytherapy experience. Commercially available for over 50 years, the GammaMedplus iX is the fifth generation in a reliable and respected line of afterloaders. KEY FEATURES OF GAMMAMEDPLUS iX: • Fixed length treatment distance aims to help reduce errors associated with applicator-to-afterloader connection • Unique applicator end test to verify applicator connection integrity and treatment length • Distal-to-proximal source movement • Fully integrated with BrachyVision™ treatment planning system* and ARIA® oncology information system* network. • 3/24 iX unit (3 channel)** allows easy and cost-effective entry into HDR for typical treatments with minimal capital expenditure. 3. Afterloader console pulls treatment plan from ARIA 4. After patient treatment, afterloader console returns the treatment record to ARIA ARIA oncology information system ProBeam™ proton therapy system TrueBeam™ system 5. Afterloader console updates the appointment status ** PDR is not available for the GammaMedplus 3/24 model. Unique™ solution 2. Treatment plan created in BrachyVision and scheduled in ARIA 1. Patient scheduled in ARIA • Wide range of treatment accessories suitable for CT imaging BRACHYTHERAPY INTEGRATION • Upgradeable to 24 channels with little downtime to expand usage to all body sites 6. RT Summary and Patient Summary display the treatment record and dose in ARIA Trilogy® system BrachyVision treatment planning system Varian system database Eclipse™ treatment planning system

COMPREHENSIVE BRACHYTHERAPY TREATMENT FEATURES 3.5 mm long active source encapsulated into the tip of a braided cable* • Source can be installed at an activity of up to 15Ci.** • Certified for up to 5,000 transfers meeting requirements, even for heavy users. • Solid core-designed source cable permits movement in a distal to proximal direction during treatment delivery ensuring accuracy and potentially reducing errors caused by cable bunching. • Distal 200 mm of the cable is a highly-flexible braided design that facilitates movement through tight catheter turns. iX control software creates intuitive,...

Fixed length treatment distance Hardware and software safety • Combined length of the applicator and correct source guide tube is always 1300 mm. • Access to treatment delivery secured through two hardware keys and password protection. • Potentially reduces errors caused by incorrect treatment length entry since the length is always the same. • Mechanical verification of secure connection of catheters/ applicators prior to treatment delivery. Unique applicator end test • Sends the inactive source to the end of the channel and then further extends to ensure that it detects a closed-end catheter....

TECHNICAL SPECIFICATIONS Radioactive source -GammaMedplus iX • Iridium-192, metallic • Cylindrical configuration • Iridium-192 pellet- HDR: 0.6 mm diameter, 3.5 mm active length; PDR: 0.6 mm diameter, 0.5 mm active length • Capsule- HDR: 0.9 mm diameter, 4.52 mm length; PDR: 0.9 mm diameter, 2.97 mm length • Nominal activity- HDR: 370 GBq (10 Ci)*; PDR: 37 GBq (1 Ci) • Air Kerma Rate (HDR): 0.063 Gy/h (±5%) for 555 GBq at 1 m * Currently, systems in the USA are subject to regulatory restrictions of use at or below 10 Ci only. The unit has been qualified to 15 Ci, and higher activity sources may...