VARISOURCE AFTERLOADER FEATURE SHEET The VariSource™ iX afterloader with its iX control software offers compatibility with hospital networks and enhances the high dose rate (HDR) brachytherapy experience. Utilizing the latest technology, the VariSource iX offers unique features to meet your brachytherapy needs. KEY FEATURES OF VARISOURCE: • Smallest diameter source wire for potentially lower trauma with interstitial techniques and bronchial catheter designed for kink resistance • Monitor wire transit with Intelligent Drive™ force feedback system • Electronic turret for reliable and accurate transfer tube engagement • CamScale™ automated position verification system for expedited, efficient daily QA checks • Full UPS and battery back-up for safe treatment completion and automated wire recovery in a power failure Unique™ solution 3. Afterloader console pulls treatment plan from ARIA 4. After patient treatment, afterloader console returns the treatment record to ARIA ARIA oncology information system ProBeam™ proton therapy system TrueBeam™ system 2. Treatment plan created in BrachyVision and scheduled in ARIA 1. Patient scheduled in ARIA • Wide range of treatment accessories suitable for CT imaging BRACHYTHERAPY INTEGRATION • Fully integrated with BrachyVision™ treatment planning system* and ARIA® oncology information system* network 5. Afterloader console updates the appointment status fi 6. RT Summary and Patient Summary display the treatment record and dose in ARIA Trilogy® system BrachyVision treatment planning system Varian system databas

COMPREHENSIVE BRACHYTHERAPY TREATMENT • Source wire transit speed of up to 60 cm/second. 5mm long active source embedded into 0.59 mm wire • 5 mm default step size matches source length resulting in a uniform line source distribution. • Allows for the use of 18 gauge (1.27 mm) needles. • Smaller needles can mean less trauma for the patient. lr 192 line source diameter: 0.34 mm Length: 5 mm Wire diameter: • Embedded directly into the 0.59 mm tip of the wire leaving no crimps or joints that could Wire material: NiTi produce weak spots. Loaded superelastic alloy with enriched iridium, the source...

• Manage QA with a source calibration worksheet, customized QA checklists and wire positional calibration (CamScale) reports • Uninterruptible power supply isolates the system and provides enough power to complete a treatment in the case of a power failure • Integration with the BrachyVision treatment planning system and ARIA oncology information system allows for the direct download of treatment plans with the aim of achieving accurate and reliable transfer of plan data, both to and from the database. CamScale system • Internal video camera focused on a scale upon which the wires can be positioned....

TECHNICAL SPECIFICATIONS Radioactive source - Model VS2000 • Iridium-192, annealed • Cylindrical configuration • Two sources, 2.5 mm active length each, 0.34 mm diameter • Initial nominal activity: 370 GBq (10 Ci) maximum; (maximum activity: 407 GBq (11 Ci) Source wire • Iridium-192 source integrally encapsulated in a super-elastic annealed nitinol (nickel-titanium) wire with plugged and welded end • Distance from distal wire tip to active source: 1 mm • Wire diameter: 0.59 mm • Usable wire length: 150 cm Tested to the following standards: Impact ISO 2919 section 8.4 (8.4.1-8.4.3) Class 2 and ISO/TR...