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LYME DISEASE ELISA FOR THE DETERMINATION OF IgG AND IgM ANTIBODIES › Lyme disease diagnostics › Intrathecal synthesis determination in neuroborreliosis

LYME DISEASE ELISA SCREENING Differential diagnosis of Stage of Lyme disease Neuroinfections Carditis Skin diseases Arthritis and arthropathy Laboratory evidence Clinical manifestations Essential - serology IgM positive (3-6 weeks post-infection) Skin biopsy I. Early localized infection Erythema migrans II. Early disseminated infection Borrelial lymphocytoma Myocarditis Ophtalmoborreliosis Neuroborreliosis IgM positive, IgG positive or IgM negative, IgG positive III. Late disseminated infection Arthritis Acrodematitis chronica atrophicans Chronical neuroborreliosis IgM negative, IgG...

LYME DISEASEELISA FOR THE DETERMINATION OF IgG AND IgM ANTIBODIES Intrathecal synthesis For the diagnosis of neuroborreliosis it is necessary to determine the intrathecal synthesis of specific IgG or IgM antibodies. A prerequisite for its determination is parallel determination of antibodies in serum and cerebrospinal fluid. Intrathecal synthesis is expressed by so called Antibody index, which is calculated using the equation according to Reiber. For its calculation following must be measured: > Concentration of specific antibodies in serum and cerebrospinal fluid > Total antibody...

LYME DISEASEELISA FOR THE DETERMINATION OF IgG AND IgM ANTIBODIES Advantages > Recombinant antigens from the strains of the Czech Republic > Quantitative determination of IgG and IgM - monitoring of antibody levels > High sensitivity and specificity > Determination of intrathecal synthesis using VIDITAB software Catalog Number VIDIA spol. s r.o. Nad Safinou II 365 252 50 Vestec Czech Republic H EUROPEAN UNION European Regional Development Fund Operational Programme Enterprise and Innovations for Competitiveness