CVD StripAssays® Identify the most relevant genetic variations to estimate the risk for Cardiovascular Diseases Cardiovascular Diseases (CVD) are common, but in many cases can be avoided. involved in endothelial dysfunction, hyperlipidemia, hypertension, and inflammation. Atherosclerosis and venous thrombosis are the two major manifestations of CVD. Both are caused by complex interactions of environmental and genetic parameters. A combination of adverse influences (female hormone intake, immobilization, surgery or cancer) and variations in genes responsible for the coagulation system can also lead to thrombosis. An unhealthy lifestyle in combination with certain genetic variants can contribute to atherosclerosis. Relevant genes include those Testing for genetic variations and adequate prophylaxis contributes to lower CVD risks. ViennaLab CVD StripAssays® • Simple protocol for complex diagnostic questions • Manual or automated processing • No expensive lab equipment • Ready-to-use reagents • CE/IVD-labeled complete kits

CVD StripAssays® detect genetic variants associated with Cardiovascular Diseases Factor V (FV): Factor XIII (FXIII) V34L: FV Leiden (1691G>A; R506Q): represents one of the most important genetic risk factors for inherited thrombophilia; leads to activated protein C resistance; occurs in 20-50% of patients with VTE. FV R2 haplotype (H1299R): mild risk factor for thrombosis; increases CVD risk for carriers of FV Leiden. Prothrombin (PTH; Factor II) 20210G>A: carriers have about 3-fold elevated risk for cerebral and deep vein thrombosis; risk significantly increases in combination with FV Leiden;...

Beta-Fibrinogen (FGB) -455G>A: increases the risk for premature MI and ischemic stroke; confers elevated betafibrinogen plasma levels. Endothelial Nitric Oxide Synthase (eNOS; NOS3): eNOS -786T>C: Human Platelet Antigen 1 (HPA1a/b; Gp IIIa; integrin beta 3 L33P): the C allele causes a higher susceptibility to coronary heart disease. HPA1b is a risk factor for early-onset MI and stroke, particularly in smokers. eNOS 894G>T (E298D): the T allele confers an increased risk for premature MI. Angiotensin-Converting Enzyme (ACE) 287 bp insertion/deletion (I/D): represents a risk factor for MI in elder...

i=rsirxj/\/\3 ESTABLISHED INNOVATIONS IN DIAGNOSTICS CVD StripAssays® identify the most important variations in genes that are relevant for atherosclerosis and venous thrombosis. are based on reverse-hybridization of biotinylated PCR products combine probes for variants and controls in a parallel array of allele-specific oligonucleotides work with immobilized oligos on a teststrip generate test results by enzymatic color reaction easily visible to the naked eye Order Information: FV-PTH StripAssay® FV-PTH-MTHFR StripAssay® ViennaLab offers StripAssays® for a wide range of diagnostic applications....