FMF StripAssays Testing for Familial Mediterranean Fever and Risk Factors for Amyloidosis Familial Mediterranean Fever (FMF) is the most common inherited inflammatory disorder. Recurrent bouts of fever and painful inflammation in the abdomen, chest or joints, typically lasting 12 to 72 hours, characterize the condition. The most severe complication of FMF is amyloidosis, a build-up of protein deposits that ultimately leads to kidney failure. Prophylactic treatment with colchicine can prevent this and allow a normal life. FMF is caused by mutations in the MEFV gene, which encodes a protein known as pyrin or marenostrin. The spectrum of mutations varies between different ethnic groups and affects the severity of FMF, as well as the risk of developing systemic reactive (AA) amyloidosis. The homozygous condition of the serum amyloid A (SAA) isotype SAA1.1 is significantly associated with AA amyloidosis in patients with FMF.

ESTABLISHED INNOVATIONS IN DIAGNOSTICS ViennaLab FMF StripAssays® • Simple protocol for complex diagnostic questions • Manual or automated processing • No expensive lab equipment • Ready-to-use reagents • CE/IVD-labeled kits including DNA extraction Order Information: FMF StripAssay®: 4-230 (20 tests/kit) Manufacturer: ViennaLab Diagnostics GmbH Gaudenzdorfer Guertel 43-45 A-1120 Vienna, Austria www.viennalab.com C€ avD More details available at www.viennalab.com