Haemochromatosis StripAssays®
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Haemochromatosis StripAssays® The easy way to test for Haemochromatosis using established innovations in diagnostics Haemochromatosis Assays. Key to efficient therapy. it allows for a simple and effective treatment (therapeutic bleeding) and a virtually normal life for affected individuals. Hereditary haemochromatosis is a common genetic disorder of iron metabolism. It results in a progressive accumulation of iron in various organs, such as liver, heart and pancreas. Common complications include liver cirrhosis, diabetes, arthritis or cardiomyopathies. Premature death due to liver cancer or organ failure may occur if the condition is left untreated. Early diagnosis is of paramount importance, as Classical or type 1 haemochromatosis is caused by mutations in the HFE gene. Less common non-HFE related forms of haemochromatosis are due to mutations in other genes involved in iron metabolism, such as Transferrin Receptor 2 (TFR2) and Ferroportin (FPN1). As they all code for proteins with an important role in regulating body iron stores, mutated forms can lead to iron accumulation in tissues and organs and can ultimately disrupt their normal functions. The Haemochromatosis StripAssays® offer an easy way to identify the most common mutations in genes contributing to hereditary iron overload. Established innovations in diagnostics by ViennaLab thus aid in the early identification and effective therapy. Gene Cellular Function Iron Absorption Iron Uptake Iron Export Status wildtype mutated wildtype mutated wildtype mutated The Assays

The ViennaLab Haemochromatosis StripAssays® meet customer requirements Requirement ViennaLab’s offer Three simple steps. 6 h. Done. Probes for variants and controls combined on one teststrip. Automated or manual processing. Incubator.Thermocycler. Shaker. That is all you need. Software for interpretation of results is optional. The ViennaLab Haemochromatosis StripAssays® combine all these requirements. The ViennaLab Haemochromatosis StripAssays® • are based on reverse-hybridization of biotinylated PCR products • combine probes for variants and controls in a parallel array of allele-specific...