ESTABLISHED INNOVATIONS IN DIAGNOSTICS IL28B RealFast™ Assay The accurate way to test the therapeutic response therapy in Hepatitis C Virus (HCV) infected patients Key to a successful antiviral therapy The IL28B RealFast™ Assay helps to predict the success of antiviral therapy and sustained virologic response (SVR) in HCV infected patients. Chronic HCV infection affects around 1% of the world population and is the leading cause of cirrhosis, liver cancer and liver transplantation. Pegylated interferon/ribavirin (pegIFN/RBV) therapy is the treatment of choice for HCV infection. SRV is dependent on virus genotype as well as on patients' factors including genetic polymorphisms. The TT>AG variant in the IFNL4 gene is the strongest known host factor for predicting HCV clearance. Genotyping of TT>AG helps to predict the outcome of pegIFN/RBV therapy independent of a patient's ethnicity. The TT>AG dinucleotide frame-shift variant appears, if present, in the human interferon lambda 4 (IFNL4) gene/ pseudogene, which is located upstream of the gene encoding interleukin 28B (IL28B). Homozygous carriers of the favorable TT allele are predisposed to an up to 3-fold higher sustained virological response (SVR) than carriers of the AG allele. ViennaLab RealFast™ Assays Fast and easy handling • Less than 90 min from DNA to result • Ready-to-use reagents • Include controls for wild type and mutant genotype • Compatible with various real-time PCR instruments ^ Available in different pack sizes (100 reactions and 32 reactions) For more details please visit: www.viennalab.com REF: IL28B RealFast™ Assay: 7-200 (100 reactions) IL28B RealFast™ Assay: 7-203 (32 reactions)

I=1X11X1/\ /\5 ESTABLISHED INNOVATIONS IN DIAGNOSTICS * not suitable for ultrafast cycling on the MIC qPCR Cycler Additional diagnostic applications that are covered by ViennaLab RealFast™ Assays: Carbamazepine Hypersensitivity, Liquid Profiling, Congenital Adrenal Hyperplasia. Mil Manufacturer: ViennaLab Diagnostics GmbH Gaudenzdorfer Guertel 43-45 A-1120 Vienna, Austria t: (+43-1) 8120156-0 C€ USB More details available at