PGX-HIV StripAssay

PGX-HIV StripAssay

PGX-HIV StripAssay

Product catalog summary
Overview: The document discusses the PGX-HIV StripAssay®, a diagnostic tool designed to identify genetic markers that influence the effectiveness of highly active antiretroviral therapy (HAART) in HIV-positive patients. The assay focuses on genetic variations in MDR1, CYP2D6, and CCR5 genes, which affect drug resistance, metabolization, and cellular entry of HIV, respectively.
Key Specifications:
  • Genes Analyzed: MDR1 (3435 C>T), CYP2D6 (*3/*4/*6), and CCR5 (32 bp deletion).
  • Assay Methodology: The assay uses reverse-hybridization of biotinylated PCR products, combining probes for variants and controls on a test strip.
  • Detection: Results are generated through an enzymatic color reaction visible to the naked eye.
Procedure:
  1. Amplification: Multiplex PCR with simultaneous biotin-labeling using a thermocycler.
  2. Hybridization: Conducted directly on the StripAssay® test strips using an incubator.
  3. Identification: Labeled products are detected by streptavidin-alkaline phosphatase, visible to the naked eye or via scanner and software.
Benefits:
  • Efficiency: The assay provides a quick and reliable method to tailor HAART based on individual genetic profiles, potentially improving therapy response and minimizing side effects.
  • Ease of Use: Requires minimal equipment (thermocycler, incubator, shaker) and offers both automated and manual processing options.
  • Affordability: Designed to be cost-effective with easy interpretation of results.
Additional Information: The PGX-HIV StripAssay® is manufactured by ViennaLab Diagnostics GmbH, Austria, and meets ISO 13485 standards. More details can be found at www.viennalab.com.
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Catalog excerpts

PGX-HIV StripAssay-1

IE^SJPsJ/\ ESTABLISHED INNOVATIONS IN DIAGNOSTICS PGX-HIV StripAssayTest for genetic markers that influence highly active antiretroviral therapy (HAART) in HIV-positive patients PGX-HIV Assay. Key to efficient therapy. Highly active antiviral therapy (HAART), the combined use of different types of antiretroviral drugs, can efficiently combat AIDS. HAART works most effectively, and side effects can be minimized when genetic variations of the individual patient are taken into account. Genetic parameters of the individual patient contribute to differences in the response to HAART. Such factors affect the uptake or inactivation of HAART components and include allelic variants of the multidrug transporter P-glycoprotein 1 (MDR1), cytochrome P450 isozyme 2D6 (CYP2D6) and the C-C chemokine receptor 5 (CCR5). ViennaLab's PGX-HIV StripAssay® offers an easy way to identify the most relevant genetic variations influencing highly active antiretroviral therapy (HAART).

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PGX-HIV StripAssay-2

ESTABLISHED INNOVATIONS IN DIAGNOSTICS The ViennaLab PGX-HIV StripAssay® meets customer requirementsRequirement ViennaLab’s offer Easy Three simple steps. 6 h. Done. Reliable Probes for variants and controls combined on one teststrip. Versatile Automated or manual processing. Incubator.Thermocycler. Shaker. That is all you need. Software for interpretation of results is optional. • is based on reverse-hybridization of biotinylated MDR1 (3435 C>T), CYP2D6 (*3/*4/*6) PCR products and CCR5 (32 bp deletion) • combines probes for variants and controls in a parallel array of allele-specific oligonucleotides...

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*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.