SLCO1B1 RealFast Assay

Product catalog summary

Overview: The document provides information on ViennaLab's RealFast™ Assays, which are designed for fast and efficient genetic testing. These assays are used to detect various genetic markers associated with different health conditions and drug responses.

Key Features:

Fast processing time of less than 90 minutes from DNA to result.
Ready-to-use reagents with controls for wild type and mutant genotypes.
Compatibility with various real-time PCR instruments.
Available in pack sizes of 100 and 32 reactions.

Applications:

Statin Therapy: The SLCO1B1 c.521T>C RealFast™ Assay helps determine the risk of simvastatin-induced myopathy, which is higher in patients with the c.521C allele. The assay aids in adjusting simvastatin doses to minimize adverse effects.
Cardiovascular Diseases: Assays like FGB -455G>A, FV Leiden, and others identify genetic predispositions to conditions like atherothrombosis and venous thromboembolism.
Genetic Predisposition: Assays for detecting alleles like HLA-B27, associated with ankylosing spondylitis, and HFE mutations, linked to hereditary haemochromatosis.
Pharmacogenetics: Assays such as HLA-B5701 and IL28B help predict drug responses and hypersensitivity, particularly for HIV and Hepatitis C treatments.

Multiplex Testing: ViennaLab offers multiplex assays that allow simultaneous detection of multiple genetic mutations, saving costs and sample material. Examples include assays for cardiovascular diseases and haemochromatosis.

Additional Information: The document mentions other diagnostic applications covered by ViennaLab RealFast™ Assays, such as Carbamazepine Hypersensitivity and Congenital Adrenal Hyperplasia.

Contact Information: ViennaLab Diagnostics GmbH, based in Vienna, Austria, is the manufacturer and distributor of these assays. More details can be found on their website.

Catalog excerpts

SLCO1B1 c.521T>C RealFast™ AssayThe easy way to determine the response to statin therapy and thus avoid dose-dependent adverse events Lower risk for simvastatin induced myopathy through established innovations in diagnostics Statins (e.g. Simvastatin) are most widely prescribed as treatment for low-density lipoprotein cholesterol reduction and control. In general statins are considered as safe and well tolerated drugs. However, some patients experience severe side effects and opt to discontinue therapy. The clinical spectrum may range from frequent pain with or without evidence of muscle degradation to a very rare but severe muscle damage with acute kidney injury (rhabdomyolysis). Patients carrying the SLCO1B1 c.521 C allele have a higher risk of simvastatin induced myopathy and rhabdomyolysis. The Clinical Pharmacogenetic Implementation Consortium (CPIC) highly recommends to adjust simvastatin dose according to the SLCO1B1 c.521T>C genotype. The SLCO1B1 gene codes for the solute carrier organic anion transporter family member 1B1 protein and affects the uptake and metabolism of statins in the liver. The risk for simvastatin-related myopathy is dose-dependent and 4 times higher in patients carrying one c.521T>C allele and 17 times higher in homozygous patients (CC). ViennaLab RealFast™ Assays '• Fast and easy handling • Less than 90 min from DNA to result • Ready-to-use reagents • Include controls for wild type and mutant genotype • Compatible with various real-time PCR instruments ^ Available in different pack sizes (100 reactions and 32 reactions) For more details please visit: www.viennalab.com

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I=1X11X1/\ /\5 ESTABLISHED INNOVATIONS IN DIAGNOSTICS * not suitable for ultrafast cycling on the MIC qPCR Cycler Additional diagnostic applications that are covered by ViennaLab RealFast™ Assays: Carbamazepine Hypersensitivity, Liquid Profiling, Congenital Adrenal Hyperplasia. Mil Manufacturer: ViennaLab Diagnostics GmbH Gaudenzdorfer Guertel 43-45 A-1120 Vienna, Austria t: (+43-1) 8120156-0 C€ USB More details available at

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