SLCO1B1 RealFast Assay
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SLCO1B1 RealFast Assay - 1

SLCO1B1 c.521T>C RealFast™ AssayThe easy way to determine the response to statin therapy and thus avoid dose-dependent adverse events Lower risk for simvastatin induced myopathy through established innovations in diagnostics Statins (e.g. Simvastatin) are most widely prescribed as treatment for low-density lipoprotein cholesterol reduction and control. In general statins are considered as safe and well tolerated drugs. However, some patients experience severe side effects and opt to discontinue therapy. The clinical spectrum may range from frequent pain with or without evidence of muscle degradation to a very rare but severe muscle damage with acute kidney injury (rhabdomyolysis). Patients carrying the SLCO1B1 c.521 C allele have a higher risk of simvastatin induced myopathy and rhabdomyolysis. The Clinical Pharmacogenetic Implementation Consortium (CPIC) highly recommends to adjust simvastatin dose according to the SLCO1B1 c.521T>C genotype. The SLCO1B1 gene codes for the solute carrier organic anion transporter family member 1B1 protein and affects the uptake and metabolism of statins in the liver. The risk for simvastatin-related myopathy is dose-dependent and 4 times higher in patients carrying one c.521T>C allele and 17 times higher in homozygous patients (CC). ViennaLab RealFast™ Assays '• Fast and easy handling • Less than 90 min from DNA to result • Ready-to-use reagents • Include controls for wild type and mutant genotype • Compatible with various real-time PCR instruments ^ Available in different pack sizes (100 reactions and 32 reactions) For more details please visit: www.viennalab.com

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SLCO1B1 RealFast Assay - 2

I=1X11X1/\ /\5 ESTABLISHED INNOVATIONS IN DIAGNOSTICS * not suitable for ultrafast cycling on the MIC qPCR Cycler Additional diagnostic applications that are covered by ViennaLab RealFast™ Assays: Carbamazepine Hypersensitivity, Liquid Profiling, Congenital Adrenal Hyperplasia. Mil Manufacturer: ViennaLab Diagnostics GmbH Gaudenzdorfer Guertel 43-45 A-1120 Vienna, Austria t: (+43-1) 8120156-0 C€ USB More details available at

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