i=rsjfsj/\/\3 ESTABLISHED INNOVATIONS IN DIAGNOSTICS Sugar Intolerance StripAssays The easy way to test for Sugar Intolerance using established innovations in diagnosticsSugar Intolerance Assays. Key to a personalized diet. Lactose and fructose are among the most common sugars in human diet, but not all people have the necessary enzymes in sufficient quantities to completely digest them. Mutations in the genes for metabolic enzymes or transporters can cause hereditary sugar intolerance. People who suffer from this intolerance may experience severe discomfort when eating lactose or fructose. Common symptoms include abdominal bloating and pain, vomiting, diarrhea, nausea, flatulence, and hypoglycemia. Fructose intolerance may ultimately cause death due to liver and kidney damage. Two variants (-13910 T/C, -22018 A/G) in an upstream regulatory region of the LCT gene correlate with the age-related decline of lactase activity. Lactase nonpersistence (adult-type hypolactasia) causes intolerance to dietary lactose in the majority of people worldwide. Hereditary fructose intolerance (HFI) is caused by mutations within the coding region of aldolase B, a key enzyme in the metabolism of dietary fructose. Four mutations (del4E4, A149P, A174D, N334K) cover >85% of known aldolase B gene variations. The Sugar Intolerance StripAssays® offer an easy way to identify the most frequent genetic variants in the genes that contribute to lactose or fructose intolerance. Function

i=rsjfsj/\/\3 ESTABLISHED INNOVATIONS IN DIAGNOSTICS The ViennaLab Sugar Intolerance StripAssays® meet customer requirements ViennaLab’s offer Three simple steps. 6 h. Done. Probes for variants and controls combined on one teststrip. Automated or manual processing. Incubator.Thermocycler. Shaker. That is all you need. Software for interpretation of results is optional. The ViennaLab Sugar Intolerance StripAssays® combine all these requirements. The ViennaLab Sugar Intolerance StripAssays® • are based on reverse-hybridization of biotinylated PCR products • combine probes for variants and controls...