Bonabone and Bonamem

Product catalog summary

Introduction
This document provides an overview of Bonabone™ and Bonamem™, two products designed for bone regeneration and tissue repair. Bonabone™ is a natural bone grafting material derived from bovine cancellous bone, while Bonamem™ is a collagen membrane derived from porcine pericardium, used in guided tissue regeneration.

Bonabone™ Specifications
Bonabone™ is composed of carbonated hydroxyapatite (CHAp) with a Ca/P ratio of approximately 1.66 to 1.67, similar to natural bone. It features high wettability, a specific surface area greater than 85m²/g, and a gradient porous interconnected structure. The porosity is 80% for 0.25-1.0mm particles and 90% for 1.0-2.0mm particles, with macropores, micropores, and nanopores supporting angiogenesis and osteoblast activity.

Bonamem™ Specifications
Bonamem™ retains a 3D porous collagen structure with high mechanical strength, softness, conformability, and hydrophilicity. It has a degradation period of 3 to 6 months and 80% porosity, promoting early vascularization and new bone formation.

Procedures and Techniques
The manufacturing process for Bonabone™ includes special degreasing and deproteinization purification technologies, ensuring no chemical or organic residues remain. Bonamem™ is used in guided tissue regeneration (GTR) and corticotomy-assisted bone grafting, acting as a barrier to guide periodontal tissue regeneration.

Norms and Standards
Bonabone™ is certified under ISO13485, indicating compliance with international standards for medical devices. Various studies support the efficacy and safety of both Bonabone™ and Bonamem™.

Applications and Benefits
Bonabone™ enhances bone conduction, supports angiogenesis, and promotes osteoblast differentiation. Bonamem™ prevents unwanted cell migration, maintains space for bone formation, and integrates with surrounding tissue. Both products offer significant advantages in bone regeneration and tissue repair.

Key Data and Findings
X-ray diffraction measurements show that Bonabone™ has a diffraction angle with a low peak similar to human bone. Bonamem™ exhibits significant tensile strength, outperforming double-layer membranes, and demonstrates good biocompatibility and biodegradability.

Case Studies
Several clinical cases demonstrate the effectiveness of Bonamem™. In one case, a 30-year-old female with severe soft and hard tissue defects underwent successful treatment with Bonamem™, resulting in reduced probing depth and stable bone grafts. Another case involved an 18-year-old male requiring corticotomy-assisted orthodontic treatment, where Bonamem™ facilitated accelerated tooth movement and bone volume increase.

Conclusion
Bonabone™ and Bonamem™ offer reliable and effective solutions for bone regeneration and tissue repair, with their natural compositions and advanced manufacturing processes ensuring high compatibility and performance in clinical applications.

Catalog excerpts

certified ISO13485 small size medium size large size DENTAL TISSUE REGENERATION SOLUTION TM Specifications are subject to change without any notice. Some products listed in this catalog are not available for sales in all markets due to pending regulatory clearance. Please contact the local sales representative for current products availability. 1. Schmid J, Hammerle CH, Stich H, Lang NP. Supra-plant, a novel implant system based on the principle of quidedbone generation. A preliminary study in the rabbit. Clin Oral lmplants Res 1991;2:199-202. 2. Linde A, Thor é n C, Dahlin C, Sandberg E. Creation of new bone by an osteopromotive membrane tech-nique: Anexperimental study in rats,J Oral Maxillo-fac Surg 1993;51:892-897. 3.Omar,Elgali, Dahlin& Thomsen,2019; Retzepi & Donos, 2010. 4.Sbricol, L.; Guazzo, R.; Annunziata, M.; Gobbato, L.; Bressan, E.; Nastri, L. Selection of Collagen Membranes forBone Regeneration: A Literature Review.Materials 2020.13.786. 5.Data from intemel research center 6.Rothamel et al, The international journal of Oral & Maxilofacial implants Vol. 27 Number 1. 2012, 146-1547.You P, Liu Y, Wang X, Li B, Wu W,T ang L, Acellular pericardium: A naturally hierarchical, osteoconductive, andosteoinductive biomaterial for guided bone regeneration. J Biomed Mater Res A. 2020 May 22. doi: 10.1002/-ibm.a.37011 7. internal data 8. N.A.S. Mohd Pu’ ad, P. Koshy, H.Z. Abdullah, M.I. Idris, T.C. Lee. Syntheses of hydroxyapatite from natural sources. Heliyon, 5 (2019), pp. e01588 9. Synthesis and characterization of B-type carbonated hydroxyapatite materials: Effect of carbonate content on mechanical strength and in vitro Boletín de la Sociedad Española de Cerámica y Vidrio Volume 63, Issue 4, July–August 2024, Pages 255-267 10. Carbonate substituted hydroxyapatite: resorption by osteoclasts modifies the osteoblastic response J.Biomed. Mater. Res. A.2009;90:217-224 11. Spense G., Patel N., Brooks R., Rushton N. 2010. Osteoclastogenesis on hydroxyapatite ceramics: The effect of carbonate substitution. J Biomed Mater Res A. 2010 Mar 15;92(4):1292-300. 22:137–148. 12. Landi E., Celotti G., Logroscino G., Tampieri A. 2003. Carbonated Hydroxyapatite as Bone Substitute. Journal of the European Ceramic Society 23: 2931–2937. 13. Spense G., Patel N., Brooks R., Rushton N. 2009. Carbonate Substituted Hydroxyapatite: Resorption by Osteoclasts Modifies the Osteoblastic Response. Journal of Biomedical Materials Research Part A 217-224 14. In vitro Study on the Osteoconductivity of Bioabsorbable Porous Carbonated Hydroxyapatite Scaffolds Journal of Oral and Maxillofacial Surgery Volume 03, 2014 15. The crystallinity of bone mineral Journal of Materials Science Volume 11, pages 1691–1696, (1976) 16. internal data 17. Zhang J, Sun L, Luo X, Barbieri D, de Bruijn JD, van Blitterswijk CA, Moroni L, Yuan H. Cells responding to surface structure of calcium phosphate ceramics for bone regeneration. J Tissue Eng Regen Med. 2017 Nov;11(11):3273-3283. doi: 10.1002/term.2236. Epub 2017 Feb 8. PMID: 28176491. 18. Xiaogang W. et al. Calcium phosphate-based materials regulate osteoclast-mediated osseointegration, Bioactive Materials, Volume 6, Issue 12, 2021 natrual bone graft Beijing Waldent Biotech Co., Ltd. 6 Floor, Building No.13, 2nd Sector, No.31, Kechuang 13 Street, BDA, Beĳing, 100176 China Copyright©2024 Beĳing Waldent Biotech Co., Ltd. All rights reserved.

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NEXTGEN CHAP IENT BIONIC STRUC GRAD TUR E The main component of animal-derived bone substitutes is hydroxyapatite, which is similar to human bone. It is the core of the success of oral guided bone regeneration (GBR) surgery and bone grafting surgeries caused by various bone defects. SEM 5000X SEM 40X Bonabone™ is a natural bone grafting material made from traceable bovine cancellous bone. Its component is Carbonated hydroxyapatite (CHAp). It is manufactured by adopting a unique multi-step temperature controlled (low-temperature) calcination and special degreasing and deproteinization purification...

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NATURAL BOVINE-DERIVED CHAP There exists a carbonate substitution structure accounting for 4-8wt.% in human bone. After special calcination treatment, the bovine cancellous bone selected for Bonabone™ retains the A/B dual-type carbonate substitution structure (there are characteristic absorption waves of carbonate ions near 878cm-1 and 1455cm-1 in the IR spectrum absorption). Among them, the A-type carbonate substitution structure has higher stability and lower solubility, while the crystal structure substituted by the B-type carbonate is more easily dissolved and metabolized [9,11,12]. This...

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GRADIENT BIONIC STRUCTURE Bonabone™ retains the natural morphological structure of bovine cancellous bone and has an internally interconnected porous structure that mimics human bone. After effectively removing organic substances such as lipids, it provides a gradient distribution, including the reasonable retention of nanopores, microscopic pores, and macroscopic pores. This enables Bonabone™ to quickly adsorb blood. After being implanted into the defect site and forming a blood clot, it can stably form a mass without loosening and supports the ingrowth of early angiogenesis. In addition, the...

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