Bonabone Bone graft

Product catalog summary

Introduction
Bonabone™ and Bonamem™ are advanced biomaterials for bone regeneration and tissue repair. Bonabone™ is a bone substitute with a Ca/P ratio similar to natural bone, enhancing biocompatibility and bone growth. Bonamem™ is a collagen membrane from porcine pericardium, used in guided tissue and bone regeneration.

Specifications of Bonabone™
- Ca/P Ratio: Approximately 1.66 to 1.67, promoting osteoblast and osteoclast activity.
- Structure: High wettability, specific surface area (>85m²/g), and gradient porous interconnected structure.
- Porosity: 80% for 0.25-1.0mm particles, 90% for 1.0-2.0mm particles.
- Pore Sizes: Macropores (>95µm) for angiogenesis, micropores (1-10µm) for cell anchoring, nanopores (<150nm) for particle adhesion.

Specifications of Bonamem™
- Material: Derived from natural porcine pericardium, retaining a 3D porous collagen structure.
- Properties: High mechanical strength, softness, conformability, and hydrophilicity.
- Degradation Period: 3 to 6 months.
- Porosity: 80%, facilitating early vascularization and bone formation.

Procedures and Applications
- Bonabone™: Used for bone defect sites, forming stable masses that support angiogenesis and bone growth.
- Bonamem™: Applied in oral surgeries for guided tissue and bone regeneration, blocking non-relevant cells and promoting vascularization.

Performance and Benefits
- Bonabone™: Mimics human bone structure, enhances blood adsorption, and supports osteoblast differentiation.
- Bonamem™: Offers optimal barrier protection, high tear resistance, and easy manipulation, with excellent cell adhesion and space maintenance.

Conclusion
Both Bonabone™ and Bonamem™ provide significant advantages in bone regeneration and tissue repair, enhancing biocompatibility, stability, and effectiveness in clinical applications.

Overview of Bonamem™
Bonamem™ is a versatile membrane used in dental procedures, applicable in both dry and wet conditions. It is thin yet strong, with excellent hydrophilicity, allowing it to adhere well to wound surfaces. It can be easily repositioned and has high tensile strength, outperforming double-layer membranes.

Biocompatibility and Biodegradability
Studies on beagle dogs show that Bonamem™ retains porcine pericardium fibers 12 weeks post-surgery, indicating its durability and gradual biodegradation, supporting new bone formation.

Clinical Cases
Case 1: A 30-year-old female with soft and hard tissue defects underwent GTR using Bonamem™, resulting in complete soft tissue coverage and stable bone particles.
Case 2: An 18-year-old male with a traumatic injury underwent corticotomy-assisted surgery. Bonamem™ provided spatial stability, promoting new bone formation and soft tissue healing.
Case 3: A 25-year-old male with chronic periodontitis underwent GTR, resulting in successful tissue regeneration and improved periodontal health.

Conclusion
Bonamem™ is effective in various dental procedures, providing stability and promoting healing in both soft and hard tissues. Its application in GTR and corticotomy-assisted surgeries demonstrates its versatility and efficacy in dental treatments.

Introduction to Dental Implant Procedures
This document provides an overview of dental implant procedures involving GBR and GTR for anterior teeth restoration, including case studies, treatment plans, and clinical outcomes.

Case Study 1: Y-Stage Implant Placement
- Patient Profile: 45-year-old male with anterior tooth loss.
- Treatment Plan: Early-stage implantation with bone augmentation using FDBA and Bonamem™.
- Outcome: Successful restoration with temporary and final restorations over a year.

Case Study 2: GTR for Mandibular Anterior Teeth
- Patient Profile: 25-year-old male with gingival bleeding and tooth mobility.
- Treatment Plan: Periodontal therapy, root canal treatment, and GTR procedure.
- Outcome: Improved gingival health and stability of tooth 32.

Technical Specifications and References
Details on materials used, such as Bonamem™ and Bonabone™, and references to studies supporting the techniques and materials used.

Conclusion
The document highlights the effectiveness of GBR and GTR in dental restoration, emphasizing the importance of material selection and procedural details for successful outcomes.

Catalog excerpts

certified ISO13485 small size medium size large size DENTAL TISSUE REGENERATION SOLUTION TM Specifications are subject to change without any notice. Some products listed in this catalog are not available for sales in all markets due to pending regulatory clearance. Please contact the local sales representative for current products availability. 1. Schmid J, Hammerle CH, Stich H, Lang NP. Supra-plant, a novel implant system based on the principle of quidedbone generation. A preliminary study in the rabbit. Clin Oral lmplants Res 1991;2:199-202. 2. Linde A, Thor é n C, Dahlin C, Sandberg E. Creation of new bone by an osteopromotive membrane tech-nique: Anexperimental study in rats,J Oral Maxillo-fac Surg 1993;51:892-897. 3.Omar,Elgali, Dahlin& Thomsen,2019; Retzepi & Donos, 2010. 4.Sbricol, L.; Guazzo, R.; Annunziata, M.; Gobbato, L.; Bressan, E.; Nastri, L. Selection of Collagen Membranes forBone Regeneration: A Literature Review.Materials 2020.13.786. 5.Data from intemel research center 6.Rothamel et al, The international journal of Oral & Maxilofacial implants Vol. 27 Number 1. 2012, 146-1547.You P, Liu Y, Wang X, Li B, Wu W,T ang L, Acellular pericardium: A naturally hierarchical, osteoconductive, andosteoinductive biomaterial for guided bone regeneration. J Biomed Mater Res A. 2020 May 22. doi: 10.1002/-ibm.a.37011 7. internal data 8. N.A.S. Mohd Pu’ ad, P. Koshy, H.Z. Abdullah, M.I. Idris, T.C. Lee. Syntheses of hydroxyapatite from natural sources. Heliyon, 5 (2019), pp. e01588 9. Synthesis and characterization of B-type carbonated hydroxyapatite materials: Effect of carbonate content on mechanical strength and in vitro Boletín de la Sociedad Española de Cerámica y Vidrio Volume 63, Issue 4, July–August 2024, Pages 255-267 10. Carbonate substituted hydroxyapatite: resorption by osteoclasts modifies the osteoblastic response J.Biomed. Mater. Res. A.2009;90:217-224 11. Spense G., Patel N., Brooks R., Rushton N. 2010. Osteoclastogenesis on hydroxyapatite ceramics: The effect of carbonate substitution. J Biomed Mater Res A. 2010 Mar 15;92(4):1292-300. 22:137–148. 12. Landi E., Celotti G., Logroscino G., Tampieri A. 2003. Carbonated Hydroxyapatite as Bone Substitute. Journal of the European Ceramic Society 23: 2931–2937. 13. Spense G., Patel N., Brooks R., Rushton N. 2009. Carbonate Substituted Hydroxyapatite: Resorption by Osteoclasts Modifies the Osteoblastic Response. Journal of Biomedical Materials Research Part A 217-224 14. In vitro Study on the Osteoconductivity of Bioabsorbable Porous Carbonated Hydroxyapatite Scaffolds Journal of Oral and Maxillofacial Surgery Volume 03, 2014 15. The crystallinity of bone mineral Journal of Materials Science Volume 11, pages 1691–1696, (1976) 16. internal data 17. Zhang J, Sun L, Luo X, Barbieri D, de Bruijn JD, van Blitterswijk CA, Moroni L, Yuan H. Cells responding to surface structure of calcium phosphate ceramics for bone regeneration. J Tissue Eng Regen Med. 2017 Nov;11(11):3273-3283. doi: 10.1002/term.2236. Epub 2017 Feb 8. PMID: 28176491. 18. Xiaogang W. et al. Calcium phosphate-based materials regulate osteoclast-mediated osseointegration, Bioactive Materials, Volume 6, Issue 12, 2021 natrual bone graft Beijing Waldent Biotech Co., Ltd. 6 Floor, Building No.13, 2nd Sector, No.31, Kechuang 13 Street, BDA, Beĳing, 100176 China Copyright©2024 Beĳing Waldent Biotech Co., Ltd. All rights reserved.

Open the catalog to page 1

NEXTGEN CHAP IENT BIONIC STRUC GRAD TUR E The main component of animal-derived bone substitutes is hydroxyapatite, which is similar to human bone. It is the core of the success of oral guided bone regeneration (GBR) surgery and bone grafting surgeries caused by various bone defects. SEM 5000X SEM 40X Bonabone™ is a natural bone grafting material made from traceable bovine cancellous bone. Its component is Carbonated hydroxyapatite (CHAp). It is manufactured by adopting a unique multi-step temperature controlled (low-temperature) calcination and special degreasing and deproteinization purification...

Open the catalog to page 2

Open the catalog to page 3

NATURAL BOVINE-DERIVED CHAP There exists a carbonate substitution structure accounting for 4-8wt.% in human bone. After special calcination treatment, the bovine cancellous bone selected for Bonabone™ retains the A/B dual-type carbonate substitution structure (there are characteristic absorption waves of carbonate ions near 878cm-1 and 1455cm-1 in the IR spectrum absorption). Among them, the A-type carbonate substitution structure has higher stability and lower solubility, while the crystal structure substituted by the B-type carbonate is more easily dissolved and metabolized [9,11,12]. This...

Open the catalog to page 4

Open the catalog to page 5

GRADIENT BIONIC STRUCTURE Bonabone™ retains the natural morphological structure of bovine cancellous bone and has an internally interconnected porous structure that mimics human bone. After effectively removing organic substances such as lipids, it provides a gradient distribution, including the reasonable retention of nanopores, microscopic pores, and macroscopic pores. This enables Bonabone™ to quickly adsorb blood. After being implanted into the defect site and forming a blood clot, it can stably form a mass without loosening and supports the ingrowth of early angiogenesis. In addition, the...

Open the catalog to page 6

All WaldentBiotech catalogs and technical brochures

Bonaplug
16 Pages

Archived catalogs

Bonabone and Bonamem
16 Pages
Bona-aid
9 Pages