ProteinWorks TA K E T H E COM P L EX IT Y OU T O F LA RG E MO L ECU L E QUANT IFICAT ION

As the therapeutic and research landscape changes from small molecule to large molecule analysis, bioanalytical laboratories seek tools that equip them with a competitive advantage. ProteinWorks™ Sample Preparation Kits, combined with robust and reliable LC-MS methods and instrumentation, allow Discovery and Early Development laboratories to achieve standardized, reproducible, and sensitive protein quantification via the surrogate peptide approach. ProteinWorks, unmatched in performance and flexibility, includes eXpress Digest Kits for fast, reproducible protein digestion, a mAb system check...

SENSITIVE REPRODUCIBLE STANDARDIZED FLEXIBLE

REPRODUCIBLE Protein quantification workflows are prone to high variability due to their complex, multi-segment nature. Assays are expected to meet acceptable accuracy and precision guidelines while providing reliable, reproducible results to make critical research decisions. ProteinWorks eXpress Digest Kits offer a streamlined, kit-based approach capable of achieving single digit intra-kit and inter-kit reproducibility across several monoclonal antibodies. For more information, reference technology brief 720005570EN. ProteinWorks eXpress Direct Digest Kit Intra-kit (within kit) reproducibility...

SENSITIVE Decisions regarding the choice of reagents, their concentrations, as well as time, temperature, and the number of steps, all affect assay sensitivity. Achieving desired detection limits can be challenging. ProteinWorks offers a universal, kit-based sample preparation method with pre-weighed, lot-traceable reagents, and simple, step-wise instructions allowing rapid quantification of infliximab down to 10 ng/mL. For more information, reference application note 720005535EN. Linear dynamic range and standard curve statistics for various plasma digestion volumes, for infliximab, trastuzumab,...