Sample Preparation and Liquid Chromatography Solutions for Quantitative
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BIOANALYSIS CONSUMABLE SOLUTIONS Liquid Chromatography Solutions for Quantitative THE SCIENCE OF WHAT'S POSSIBLE.

Waters solutions for bioanalysis, which include sample preparation products, columns, analytical standards and reagents, LC systems, mass spectrometers, and software, offer the most sensitive, robust, and reproducible results. Whether you are working in the area of discovery or development, non-regulated or regulated environments, Waters system solutions comprehensively meet the converging needs of scientists, analysts, laboratory managers, and quality assurance (QA) and informational technology (IT) professionals. For the ultimate in bioanalytical data quality, laboratory productivity, and...

BIOANALYSIS CONSUMABLE SOLUTIONS Many compounds Acceptable sensitivity Clean extracts Generic methods High sensitivity

Unique design eliminates time-consuming steps for increased throughput Precipitate-free filtrate for maximum system uptime vs. classical methods Ideally suited for cleanliness, MS compatibility, and analyte recovery

SI ROCCO P ROTE I N P RECI P I TATION P L AT E SIMPLY CLEAR T he Sirocco™ Protein Precipitation (PPT) Plate eliminates additional, time-consuming sample-handling steps traditionally done with classical PPT. Unique membrane and valve-tip technology enable the analyst to carry out in-well protein precipitation followed by the final filtration step. T his approach leads to efficient sample processing, resulting in clear filtrates from small sample volumes. Sirocco Plates can be automated to process large numbers of samples efficiently. PROCESSING TIME COMPARISON With Sirocco Plates, samples...

THE FASTER WAY TO CLEANER Ostro™ Sample Preparation Products provide a novel solution for the cleanup of phospholipids in plasma and serum. Requiring minimal to no method development and using a simple protocol, this technology can be quickly implemented to optimize your laboratory’s workflow. Providing cleaner, more reproducible extracts than competitive phospholipid removal devices or techniques, the Ostro 96-well Plate allows for more sensitive analyses, increased sample throughput, and reduced instrument downtime. PHOSPHOLIPID REMOVAL T he level of 5 phospholipids remaining after sample...

OSTRO SAMP LE P RE PARATI ON P L AT E Removes significantly more phospholipids than competitive products or techniques for cleaner extracts Improves reproducibility for more consistent, robust methods Increases throughput with easy-to-implement protocol

Highest sensitivity for traditional pharmaceutical compounds and therapeutic peptides Minimal matrix effects for LC/MS/MS analyses Unmatched product quality, performance, and reproducibility

OASI S SAMP LE E XTRAC TI ON PR ODU C T S SENSITIVITY IN ITS PUREST FORM Sensitivity is one of the key requirements for a successful bioanalytical assay. Achieving optimum sensitivity requires the isolation of compounds of interest from interferences present in biological samples. The patented Oasis® Solid-Phase Extraction (SPE) Products are available in a wide array of formats and sorbents, allowing scientists to develop methodologies that are selective for the compounds of interest. Oasis Products enable scientists to create highly accurate and reproducible SPE methods that are...

EXTREME FLEXIBILITY AND EXCEPTIONAL SELECTIVITY Due to the increased sensitivity, improved throughput, and exceptional assay reliability provided by UPLC® Technology, this system is now the platform of choice for bioanalytical assays. With four different column technologies and different particle substrates and over twenty sub-2-µm column chemistries available for small molecules and biotherapeutic applications, Waters has a wide range of column solutions to meet your application needs. As a starting point, we recommend Waters BEH C18, CSH™ C18, and BEH HILIC columns as they offer the...

BEH, CSH, AND SOLI D-CORE PARTI CLE COLUMN TECHN OLOG IE S Maximize laboratory productivity by reducing analysis time while improving data quality Reach lower limits of detection by enabling higher MS response with narrow chromatographic peaks Improve sample characterization by reducing MS suppression due to residual matrix components SOLID-CORE PARTICLE TECHNOLOGY BEH HILIC Ideal column for highly polar analytes and other difficult separations including lipids Complimentary selectivity Maximum efficiency and maximum resolution Ultimate peak capacity with the ACQUITY UPLC® System...

ANALY T I C A L S TA N DARD S AND REAG E NTS PRECISE FORMULATION AND ABSOLUTE TRACEABILITY Waters understands the importance of high quality analytical standards and reagents for ensuring continuous analytical instrumentation performance and workflow success. As a result, Waters now offers standards and reagents that are pure, precisely formulated, reproducible, and traceable to exact specifications. From system performance standards to application specific standards, Waters provides the right product for optimal results. Reduce variability in the laboratory Streamline the laboratory...

Waters understands the importance of auto sampler vials and plates for the performance of analytical instrumentation. Quality vials are essential for reliable analytical results. All Waters Certified Vials are tested by LC or LC-MS to assure quality and cleanliness. T he test results confirm the vials, cap, and septa have been properly manufactured, handled, and packaged, and are free from any potential contaminants which could result in chromatographic ghost peaks. Compatible with all autosamplers Specially designed vials and plates for limited sample volumes Complete selection of vial...

SOLUTIONS FOR THE WAY YOU’LL WORK TOMORROW Tomorrow’s pharmaceuticals will need to be more targeted, effective, safer, and get approved and to market faster than ever. To succeed in that world, you’ll need technology that is designed to support continuous improvement and a technology partner who truly understands your methods and goals. Only one company offers both: Waters. For regulated laboratories, Waters offers the Regulated Bioanalysis Platform Solution, a fully integrated platform for quantitative bioanalysis. It delivers robust assays with the highest sensitivity. T he platform...