SYSTEMIC INTRAVENOUS LOW-LEVEL-LASER THERAPY (LLLT) WITH THE WEBERNEEDLE® ENDOLASER weber medical GmbH Sohnreystr. 4 37697 Lauenfoerde Germany

Contents ABOUT SYSTEMIC LOW-LEVEL-LASER THERAPY………………………………………………………………………………………………………………………………...3 • • Biochemical effects and the role of Mitochondria History of Low-Level-Laser Therapy WEBER MEDICAL AND THE WEBERNEEDLE® ENDOLASER…………………………………………………………………………………………………………….9 • • • Introducing the Weberneedle® Endolaser About weber medical and Dr. med. Dipl. chem. Michael Weber Current and future Research Initiatives EFFECTS OF DIFFERENT WAVELENGTHS/COLOURS IN DETAIL…………………………………………………………………………………………………….19 • • • • • Red Laser Light Green Laser Light Blue Laser Light and Nitric Oxide Mechanisms...

ABOUT SYSTEMIC LOW-LEVEL-LASER THERAPY

Biochemical Mechanisms • In general, there are specific cellular structures that are able to absorb specific wavelengths (colors) of light (known as photoreceptors) • The light stimulus gives a cellular signal affecting the chemical behavior, metabolism, movement and gene expression • All associated enzymes and/or proteins are now affected • This cascade event can ripple across an entire cell Hamblin: http://photobiology.info/Hamblin.ht

Absorption of Difference Light Wavelengths (Colors) in Mitochondria One example for the absorption of different colors within cells is the process in the mitochondrial respiratory chain [21] Complex 1 (NADH dehydrogenase) absorbs blue and ultraviolet light Complex 3 (cytochrome c reductase) absorbs green and yellow light Complex 4 (cytochrome c oxidase) absorbs red and infrared lig

History of Systemic Light Therapy 1. UV Light Therapy (UVBI): • In 1903 a Nobel Price was awarded for the observation that cutaneous TB can be cured by UV light. The practice of UV light therapy began in the 1920s when a UV therapy device was developed for extracorporeal treatment of the blood by Emmet Knott The technique was called Ultraviolet Blood Irradiation (UVBI), Hematogenous Oxygenation Therapy (HOT) or Extracorporeal Photophoresis At that time, the therapy was conducted extracorporally (withdrawal of 60 cc's of blood, brief irradiation with UV light and return into patient’s bloodstream)...

History of Systemic Light Therapy 2. Systemic Laser Therapy in Russia: • The method of intravenous laser blood irradiation was first introduced into therapy by the Soviet scientists E.N.Meschalkin and V.S.Sergiewski in 1981 [37] for the treatment of cardiovascular diseases A red light laser (632nm) with a power of 1-3 mW was used for 20-60 min Improvement of rheologic properties of the blood as well as improvement of microcirculation and reduction of the area of infarction had been proved. Further reductions of dysrhythmia and sudden cardiac death occurred [5,24] In the years after, many (for...

History of Systemic Light Therapy First machine with red laser 635nm according to Russian technology was approved in Europe in 2005 First case studies on patients confirmed Russian data Distribution of technology started with simulatenous collection of data and studies from different clinics In 2007 first green diode was developed In 2008 first blue diode was developed In 2013 first yellow diode was developed In 2016 first ultraviolet diode was d

WEBER MEDICAL AND THE WEBERNEEDLE® ENDOLASER

* Developed with the support of German Government and European Union Weberneedle® Endolaser* with Infrared, Red, Green, Yellow, Blue and Ultraviolet Light Lasers

International Medical Approvals Health Canada US-FDA for External Laser Therapy (IV application = off-label use) TGA Australia for External Laser Therapy

Technical Information and Comparison to Other Devices The Weberneedle® laser devices are modular systems that can be equipped with up to 12 lasers with different wavelengths/ colors FDA, CE, Health Canada and other international approvals Disposables such as needles and catheters available at a reasonable price Using real lasers instead of cheap LED technology (coherent light with high specificity to various cellular components and deeper penetration in blood and tissue) All available wavelengths/ colors (infrared, red, green, blue, yellow, ultraviolet) available Weberneedle® devices can also...

About weber medical Products Made in Germany Focus on evidence-based medicine → cooperation with several research institutions Established in 2003 after many years of research and development in the field of medical lasers Received financial aid from the German government and the European Union in 2004 for the development of the world’s first multichannel laser systems for invasive laser therapy CE approval since 2005 → 12 years of clinical experience with data from more than 1500 clinics worldwide Weber Medical has quickly become one of the world’s leading companies in medical laser technology...

The Inventor: Michael Weber, MD Dr. Michael Weber is a medical practitioner for more than 30 years in Germany and leader of three medical centers for general and internal medicine, pain management and cancer treatment Besides his MD diploma he’s also a certified biochemist who is working in research with many national and international institutions and universities He is president of the International Society for Medical Laser Applications, editor in chief of the International Journal for Medical Laser Applications and co-editor of several other medical journals He is also developer of the patented...