Journal of Nursing Science Comparison of Fructose Diphosphate Sodium Infusion-induced Pain Alleviation by Different Filters of Apertures SHEN Xiaoqing, ZHOU Ge, SONG Qiong Department of Internal Medicine , Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology Abstract: For 100 patients with ischemic heart disease, Infusion Sets with Common 15μm Filters and Infusion sets with Precision Filters were used to infuse Fructose Diphosphate Sodium (FDP). The patient complaints about FDP-induced pain was recorded and analyzed. The pain levels of patients treated with two different filters were compared. Significant difference was found between two groups (P<0.01). The results showed that FDP-induced pain can be effectively alleviated by the use of Precision Infusion Filters. Key Words: Fructose Diphosphate Sodium, Precision Infusion Filter, Pain CLC No.: R472.4 Document Code: B Article ID: 1001-4152(2004)19-0028-02 FDP Injection is a commonly used clinical drug for improving myocardial ischemic angina and arrhythmia in patients with coronary heart disease. Since FDP belongs to an acidic solution, after it enters the cell, the concentration of lactic acid is increased by activating phosphofructokinase to promote glycolysis, causing spasm of vascular smooth muscle[1]. Therefore, when the patient is infused with FDP intravenously, in less serious cases the symptoms of soreness and pain may occur and transmit from the puncture point along the vein; in severe cases, the patient may have irritability, increased heart rate, mood swings and so on. About 10% of patients refused to continue taking the drug because they could not tolerate severe pain, 6% of patients had aseptic phlebitis[2]. In March 2004, our department compared the effect of Common 15μm Filter and Precision Filter on reducing the pain induced by FDP infusion. The report is as follows. 1 Objects & Methods 1.1 Objects 100 patients with ischemic heart disease who received FDP infusion were randomly selected, including 56 males and 46 females, the oldest being 73 years old and the youngest being 38 years old, with an average of 48.2 years old. All patients had no specific pain associated with medication prior to FDP treatment. 1.2 Methods 1.2.1 Infusion Method: Single blind method was adopted when patients received FDP infusion treatment. Infusion Sets with different filter pores were used alternately in the right and left limb veins. The Infusion Sets with Common 15μm Filters were used on odd days (Control Group), with 198 punctures.

Oct. 2004 Vol.19 No.19 (General Edition) Journal of Nursing Science Infusion sets with Precision Filters were used on even days (Observation Group), with 193 punctures. Flexible and easily fixed blood vessels were selected for puncture. Continuous infusions should not be given to the same blood vessel for more than 3 times. To reduce the effect of infusion rate on the results, the infusion rate was kept at 50gtt/min. 1.2.2 Evaluation Method: The patients' pain perception was evaluated with the scale of 0-10 linear visual simulation. Grades 1-4 are mild pain, grades 5-6 are moderate pain, grades...

Journal of Nursing Science Reference [1] Hunan medical college. Physiology[M]. Beijing. People's medical publishing house, 1978.336. [2] TIAN Suying. The Study on reducing intravenous stimulation caused by Fructose 1,6-bisphosphate[J], Nursing Study, 2002, 16(9): 523. [3] LI Ailing. The evaluation of 100 cases of anorectal postoperative pain with linear visual analog scale scoring[J]. Journal of Nursing Science, 1998,13(5):313. [4] WANG Hongchen. Clinical harm of particulates in infusion[J]. Pharmaceutical Bulletin, 1979, 14(2):70. [5] LV Qiang, LI Jing, LUO Yong and etc. The study on insoluble...