Gel-One® Cross-linked Hyaluronate The only single injection 3mLGel. Gel-One® Hyaluronate is a sterile, transparent, viscoelastic hydrogel approved for the treatment of pain in osteoarthritis (OA) of the knee. The unique cross-linking process enables increased viscoelasticity, which serves to provide pain relief and improved knee function. Safety and Efficacy In the Gel-One Hyaluronate clinical study, pain reliefwas measured at 1, 3, 6, 9, and 13 weeks demonstrating statistically significant improvement over the Phosphate Buffered Saline control (PBS).* Patients receiving Gel-One Hyaluronate experienced, on average, a nearly 40% reduction in pain from baseline (28 mm reduction in WOMAC pain on a 100 mm VAS, Visual Analog Scale) Structural Formula of Gel-One Hyaluronate ■Sodium tiyaluronate

Gel-One Cross-Linked Hyaluronate Injection Technique Using strict aseptic technique apply antiseptic and, if desired, local anesthetic. The knee joint space is accessed through the soft palpable anterolateral port that can be felt just lateral to the inferior pole of the patella and the proximal portion of the patella tendon. If present, remove joint effusion through an 18-20 gauge needle before injecting Gel-One Hyaluronate. Maintain needle placement in the joint while disconnecting the syringe used to remove joint effusion. Discard the syringe containing the removed joint effusion. Peel off...