FOR MINIMALLY INVASIVE NEUROSURGERY Traditional neurosurgery is performed via a craniotomy, a maximally invasive procedure that can result in long recovery times, pain, and scarring. ROSA ONE® Brain is a robotic solution to assist surgeons in planning and performing complex neurosurgical procedures through a small drill hole in the skull. The robotic technology enables surgeons to perform less invasive procedures than traditional craniotomies - enabling smaller incisions and potentially enhancing patient comfort.1

TECHNOLOGY AND FUNCTIONALITY Pre Operative Planning With ROSA ONE Brain, the surgical procedure begins before the surgeon enters the operating room. ROSA ONE’s arm is engineered with 6-degrees-of-freedom, allowing exceptional dexterity and Creating the surgical plan pre-operatively may reduce OR time and patient anesthesia time. flexibility to access surgical sites. Once trajectory has been set, the rigidity of the robotic arm reduces unintended movement. Workflow Integration ROSA ONE features force torque sensor technology, which creates a seamless interface between The high accuracy provided...

Step 2: Minimally Invasive Registration Contactless registration technology pairs laser sensors with a robotic arm to record the patient’s position and anatomy. The system executes detailed scans of the patient’s facial features - matching the scan to pre-operative images. Using this technology, registration is performed without the use of invasive landmarks. Alternatively, traditional registration methods such as skin or bone fiducials, or stereotactic frame registration may be employed. Registration technology streamlines workflow – separating the image acquisition, planning, and operative...

Registration verification Visually verify the matching anatomical landmarks PROCEDURES ROSA ONE Brain can assist in a variety of neurosurgical procedures, such as Stereo Electroencephalography (SEEG) Deep Brain Stimulation (DBS) Stereotactic Biopsy Ventricular Endoscopy Transnasal Endoscopy

Minimally invasive procedure - enhanced patient comfort1 Simplified pre-operative procedures Speed of procedures - minimizes anesthesia time3 Procedure can be performed without shaving the head STAKEHOLDER BENEFITS Zimmer Biomet is committed to providing value to surgeons, clinicians and healthcare providers, while simultaneously improving the lives of patients worldwide. ROSA ONE Brain leverages robotic-assisted technology to maximize accuracy2, speed3, and flexibility of neurosurgical procedures and help healthcare organizations manage operational costs. • Data-driven informed decisions - preoperative...

References 1. Tandon et. al. Analysis of Morbidity and Outcomes Associated with Use of Subdural Grids vs Stereoelectroencephalography in Patients with Intractable Epilepsy. JAMA Neurol. doi:10.1001/jamaneurol.2019.0098 • 2. ROSA ONE Brain Performance Bench Testing, 510(K) Premarket Notification, K182417 • 3. Gonzalez-Martinez et. al. Technique, Results, and Complications related to Robot-Assisted Stereoelectroencephalography. Neurosurgery 78:169–180, 2016. For more information on on ROSA ONE® Brain and other Surgery Assisting Technologies, please contact us at: BIOMET MICROFIXATION GLOBAL HEADQUARTERS...