Zimmer DeNovo NT Natural Tissue Graft ® Biologic treatment for early intervention and cartilage repair.

DeNovo NT Graft – Advancing the Science of Cartilage Repair. DeNovo NT Natural Tissue Graft is a juvenile cartilaginous allograft tissue intended to provide surgeons with an earlyintervention option for the repair of articular cartilage in a wide range of anatomic focal cartilage defects. It offers a single-stage procedure with fibrin fixation that eliminates the need for harvesting a periosteal flap. With DeNovo NT Graft, Zimmer demonstrates its commitment to leadership in providing surgeons – and their patients – with a complete continuum of joint care. Juvenile Cartilage Tissue DeNovo NT Graft...

Clinical Experience • Human clinical experience includes 6 years of implant history and greater than 7,000 grafts. • DeNovo NT Graft has been used to treat focal defects in a wide range of anatomical applications, including: Pre-Clinical Evidence from Studies of Bovine Chondrocytes* · Knee (i.e., condyle, trochlea, patella, tibial plateau) Relative Light Units/Second (x104) Juvenile Adult · Foot and ankle (i.e., talus, MPJ) · Elbow · Shoulder (i.e., humeral head, glenoid) · Hip (i.e., acetabulum, femoral head) • Clinical trials in both the ankle and knee demonstrate significant improvement in...

e.g., debridement, microfracture, chondroplasty, subchondral drilling, etc. 1. Liu, Zhao, Clarke, Gao, Garrett, Margerrison. Enhanced Tissue Regeneration Potential of Juvenile Articular Cartlage. Am JSp Med. 2013. In Press 3. Cole, Farr, and Tabet. Arthroscopy Association of North America Annual Meeting, April 2013. 4. Coetzee, Giza, Schon, Berlet, Neufeld, Stone, and Wilson. Treatment of Osteochondral Lesions of the Talus With Particulated Juvenile Cartilage. Foot Ankle Int, online 10 April 2013. DOI: 1071100713485739. 5. Harris, Siston, Brophy, Lattermann, Carey, and Flanigan. Failures, re-operations...