Multitasker
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z.iVAK TECHNOLOGIES FUTURE OF ANALYSIS Turn your MS/MS instrument into by adding Zivak Multitasker-LC and validated Kits

Z1VA1CAbout Zivak UNIQUE SOLUTION FROM ONE COMPANY Zivak Technologies is an international special company providing ready to use LC-MS/MS and HPLC analysis kits in the clinical diagnostics field. The Research&Development company also supplies its own fully automated sample preparation and injection systems which enables laboratories around the globe to make efficient use of their chromatography instruments as well as their employees in a fast, accurate and cost efficient way. Index © The role of LO-MS/MS in Clinical Analysis? © What is the disadvantages of LC-MS/MS? © What is the...

ZiVAK The Role of LC-MS/MS in Clinical Analysis During the past 15 years, liquid chromatography tandem mass spectrometry (LC-MS/MS) has evolved into a vital technology used to perform routine tests in many clinical laboratories. It offers analytical specificity superior to that of immunoassays or conventional high performance/pressure liquid chromatography (HPLC) for low molecular weight analytes and has higher throughput than gas chromatography-mass spectrometry (GC-MS). LC-MS/MS had been used primarily by research, pharmaceutical, or commercial laboratories; however, advances in the...

Z1VA1C On the other hand, MS/MS has superior selectivity for many analytes since it recognizes them by at least two physical properties—their precursor and product ion mass. With the introduction of soft ionization techniques, such as electrospray ionization and atmospheric pressure chemical ionization, low molecular weight molecules can be ionized in liquid phase allowing the coupling of high performance LC to MS/MS. When MS/MS is coupled with LC, the retention time adds another property to correctly identify the analyte, resulting in enhanced specificity. Clinical laboratories have also...

Z1VA1C What are the disadvantages of LC-MS/MS? Despite the numerous benefits of LC-MS/MS, it is not without challenges. As a high complexity system, LC-MS/MS requires a high level of technical expertise to develop and validate LDTs as well as troubleshoot the instruments. In addition, FDA’s recently released draft guidance document on regulating LDTs could affect the majority of tests developed and performed on LC-MS/MS. Currently, laboratories develop and validate LC-MS/MS assays according to CLIA, which established quality standards for lab testing and accreditation programs for clinical...

Z1VA1CWhat is the Automation? Zivak Technologies has developed state of the art sample preparation system tor Mass Spectrometry devices. The system can be connected to different brand of MS/MS systems like Shimadzu, Agilent, Waters, Thermo and ABI Sciex which supported TTL connection protocol. Zivak MULTITASKER is the automated UHPLC system with built-in sample preparation which enables to automate major LC-MS/MS analyses in the clinical laboratories such as Vitamin D2/D3, Amino acids, Organic acids, Immunosuppressant Drugs without any human intervention from primer sample collection tube....

Z1VA1CMULTITASKER: Direct LIS transfer from beginning to end Zivak Multitasker was especially designed for routine testing for the clinical labs. Zivak Multitasker enables to make Vitamin D2/D3, Amino acids, Organic acids. Immunosuppressant Drugs and the other major LC-MS/MS analyses fully automated - without any human intervention- from primer sample tube after the technician place the samples on the sample tray. The Multitasker system automatically generates sample sequence by reading barcode from primary sample tube which barcoded by Hospital LIS system. PLACE YOUR SAMPLES AS YOU GET...

Z1VA1C MULTITASKER: Automated Sampling § Preparation from Primary sample tube All sample preparation steps for LC-MS/MS analyses made by the unique modules of Multitasker The volume of samples is not an issue for the system since Liquid Level Sensing capability from closed lid sample tubes. Zivak Multitasker improves the precision and accuracy of the clinical LC-MS/MS analysis. © Barcode reading from sample tube. © Sample transfer from sample tube. © Reagent adding. Vortex mixing. Centrifuge. © On-line SPE. Injection and triggering MS acquisition.

Z1VA1C MULTITASKER: Automated 25-OH Vitamin D2-D3 LC-MS/MS Analysis There are many scientific studies and papers showing inaccuracy of commercial immunoassays measuring total Vitamin D. It is recommended that any Vitamin D assay in clinical laboratories should measure both vitamin D2 and vitamin D3 separately in order to report a total Vitamin D concentration. LC-MS/MS and HPLC are direct analysis methods used routinely for differential measuring of 25-hydroxy metabolites of vitamin D2 and D3. Zivak Multitasker enables to analyze Vitamin D2 and D3 samples fully automated in MS/MS...

ZiVAK MULTITASKER: Automated Immunosuppressants LC-MS/MS Analysis Immunosuppressants are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) and treat autoimmune diseases or diseases that are most likely of autoimmune origin. Most of the immunosuppressants require monitoring blood concentrations, which called as therapeutic drug monitoring (TDM), for dosage adjustment. The measurement of low drug concentrations seen in biological fluids...

Sample Chromatograms and Validation Results Sample chromotograms are for serum calibrator of Zivak 25-OH Vitamin D2/D3 LC-MS/MS Analysis Kit Zivak Technologies • +90212 2106215 • wwwzivak.com

Z1VA1C MULTITASKER: Automated Quantitative Organic Acids LC-MS/MS Analysis Quantitative analysis of the organic acids in urine samples has clinical importance for determining organic acidemias and monitoring the organic acid concentrations in human urine. LC-MS/MS is an influential device for the study of metabolic disorders. Zrvak Multitasker enables to analyze Organic acids samples fully automated in MS/MS instruments - without any human intervention- from urine collection tube. Zivak Multitasker system can inject from closed cap urine tube if needed. This eliminates the contamination...