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MULTITASKING SYSTEMS, LC-MS/MS and HPLC ANALYSIS KITS

Main methods and procedures that have been ZIVAK TECHNOLOGIES Eski Besiktas Cad. No 44, 34400 ISTANBUL - TURKEY

About Zivak® Technologies Zivak® Technologies is an international special company providing ready to use LC-MS/MS and HPLC analysis kits in the clinical diagnostic field. Zivak® Technologies supplies also its own fully automated sample preparation and injection system which enables laboratories around the globe to make efficient use of their LC-MS/MS instruments as well as HPLC instruments in a fast, accurate and cost efficient way. Zivak® Technologies' Head Office is in Istanbul/Turkey. Sales and marketing activities are carried out in more than 70 countries, either directly by the...

MULTITASKING SYSTEMS Multitasking System of 25-OH Vitamin D2/D3 Multitasking System of Immunosuppressants Flexible Multitasking System LC-MS/MS ANALYSIS KITS in Human Serum Samples in Human Whole Blood Samples _ in Human Urine Samples < Amino Acids Stfrwb

Neonatal Screening in Dried Blood Spots in Human Urine Samples in Human Urine Samples in Human Urine Samples Psychoactive Drugs in Human Urine Samples Total Homocysteine in Human Plasma Samples in Human Serum & Plasma and Dried Blood Samples

HPLC-UV ANALYSIS KITS in Human Serum Samples in Human Serum & Plasma and Dried Blood Samples HAEMOGLOBIN ANALYSIS KITS & ANALYSER in Whole Blood Samples Haemoglobin Variants in Whole Blood Samples

MULTITASKING SYSTEMS Multitasking System of Vitamin D2/D3 LC-MS/MS Analysis Multitasking System of Immunosuppressants LC-MS/MS Analysis Flexible Multitasking System of LC-MS/MS and HPLC Analysis

LC-MS/MS Analysis available Afunique combination Suitable for all LC-MS/MS instruments receive results fully automated Tested by NIST with an accuracy of 96% CE-IVD certified ! Cost Effective

LC-MS/MS Analysis available Sample Chromatograms and Validation Results Sample chromatograms are for serum calibrator of Zivak® 25-OH Vitamin D2/D3 LC-MS/MS Analysis Kit Precision Intra-Assay Precision Inter-Assay Precision Intra-Assay Precision Inter-Assay The test results have been validated with an AB Sciex API 4000 LC-MS/MS instrument in Nov. 2014.

LC-MS/MS Analysis available Place blood collection tube with Zivak® - Multitasker fully automated CE-IVD certified ! Cost Effective

LC-MS/MS Analysis available Automated Barcode Reading Sample Preparation Sample Injection Validation Results Precision Intra-Assay <%cvi The test results have been validated with an AB Sciex API 4000 LC-MS/MS instrument in Nov. 2014. Suitable for all LC-MS/MS instruments

Zivak® - Multitasker for LC-MS/MS and HPLC Analysis Customise your Zivak® Flexible Multitasker with optional modules !

Zivak® - Multitasker for LC-MS/MS and HPLC Analysis Zivak® Full Automated Analysis Kits Psychoactive Drugs Organic Acids Manual LC-MS/MS Analysis Kits in Human Serum Samples in Human Urine Samples in Human Urine Samples in Whole Blood Samples for Dried Blood Spots Samples ►Total Homocysteine in Human Plasma Samples in Human Urine Samples in Human Urine Samples in Human Serum & Plasma Samples Quantitative Amino Acids in Biological Fluids Samples in Human Urine Samples Manual HPLC-UV Analysis Kits 25-OH Vitamin D2/D3 quantitative Determination of PKU in Human Serum Samples in Human Serum &...

•T LC-MS/MS ANALYSIS KITS I ^ ^ in Human Serum Samples ^ | in Human Whole Blood Samples in Human Urine Samples Amino Acids Neonatal Screening in Dried Blood Spots in Human Urine Samples in Human Urine Samples in Human Urine Samples Psychoactive Drugs in Human Urine Samples in Human Plasma Samples in Human Serum & Plasma and V Dried Blood Samples ^^L*

in Human Serum Samples VITAMIN PROFILING with high accuracy LC-MS/MS System Main methods and procedures that have been • Also available with Zivak® Multitasker Full Automated Sample Preparation AND Injection System • 1.7 minutes analysis time • Sensitive separation with Zivak® 25-OH Vitamin D UHPLC column • Approximately 1000 analysis with one column Reference upon request

in Human Serum Samples VITAMIN PROFILING Sample Chromatograms and Validation Results Sample chromatograms are for serum calibrator of Zivak® 25-OH Vitamin D2/D3 LC-MS/MS Analysis Kit Precision Intra-Assay <%cv> The test results have been validated with an AB Sciex API 4000 LC-MS/MS instrument in Nov. 2014.

in Human Whole Blood Samples DRUG MONITORING selective analysis with an deuterated internal standards LC-MS/MS System Main methods and procedures that have been • Also available with Zivak® Multitasker Full Automated Sample Preparation AND Injection System • 2 minutes analysis time • Sensitive separation with Zivak® Immunosuppressants HPLC column • Deuterated internal standards • Approximately 1000 analysis with one column

in Human Whole Blood Samples DRUG MONITORING Sample Chromatograms and Validation Results Sample chromatograms are for whole blood standard of Zivak® Immunosuppressants LC-MS/MS Analysis Kit The test results have been validated with an AB Sciex API 4000 LC-MS/MS instrument in Nov. 2014.

Organic Acids in Human Urine Samples Minimal sample preparation with rapid, detection of 55 organic acids LC-MS/MS System Main methods and procedures that have been selected • Also available with Zivak® Multitasker Full Automated Sample Preparation AND Injection System • 20 minutes analysis time • Sensitive separation with Zivak® Organic Acids HPLC column • Quantitative analysis of 55 major organic acids • Between 1500-2000 analysis with one column • No derivatisation, evaporation or SPE process

Validation Results The test results have been validated with an AB Sciex API 4000 LC-MS/MS instrument in Nov. 2014

Accurate, sensitive 42 free amino acids LC-MS/MS System Main methods and procedures that have been • 20 minutes analysis time • Available in Biological Fluids: Plasma, Serum, Urine, Cerebrospinal Fluid • Sensitive separation with Zivak® AA HPLC column • Deuterated internal standards • Approximately 2000 analysis with one column