COWELL® Regenerative Solution
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COWELL® REGENERATIVE SOLUTION COWELL® Regenerative Solution Inspire confidence through a comprehensive approach

® 002 • COWELL® BMP Series 010 • INNO-CaP 012 • INNO OSS & INNO OSS Allo 013 • DiaBone 014 • MEGA DERM™ Plus 016 • Diaderm® M 017 • InnoGenic™ Non-resorbable Membranes prehensive approach m onfidence thr

COWELL® REGENERATIVE SOLUTION Inspire confidence through a comprehensive approach MegaDerm™ Plus The acellular dermal matrix can carry out the functional blocks of the membrane due to its long absorption period (soft tissue penetration protection) and is the first in the world with the basement membrane layer removed to maximize the transplant engraftment rate. The world’s first E.rhBMP-2, (E.Coli derived Recombinant Human Bone Morphogenetic Protein type 2), as a growth factor that induces bone and cartilage formation. It is a retinoid mediator that plays a key role in osteoblast...

Osteoinductive Bone Graft 4. Mechanism of Action of COWELL BMP A. Migration of Cells with lamellipodia • COWELL® BMP is bone graft material based on the E.rhBMP-2 (E.Coli derived Recombinant Human Bone Morphogenetic Protein type 2), developed for the first time in the world. COWELL® BMP is supported with 10 years of clinical data and over 40 studies. A. Filopodial extensions Ror2 cdc42 Myo-x Brld brll LIMK adhesions B. Cell protrusion extracellalar space stationary cell • BCP as a carrier allows maintenance of space. GTP actin filaments microtubule microtubule organizing center • Primary...

COWELL® BMP Plus (Two vials) 5. Product Type COWELL® BMP (One vial) BMP Powder + BMP Coated BCP Particle • Dose and particle size of the COWELL® BMP Plus. le Plus • Dose and particle size of the COWELL® BMP Product Code Particle Dose Particle Size Product Code Particle Dose Particle Size Product Code Particle Dose Particle Size Particle Size Particle Size Particle Dose Product Code Particle Size Product Code Product Code Product Code Particle Size Particle Dose A vial of 0.1g can be used for less than one extraction socket, while 0.25g/0.5g can be used for maxillary sinus or for the wide...

INNO GF Kit (Two vials + Saline Solution + Syringe) 6. User Guide COWELL® BMP A. Method Saline Solution & Syringe • Dose and particle size of the INNO GF Kit. I a. Transfer BCP graft material (Vial ). b. Inject distilled water into vial with lyophilized rhBMP-2 power in it and mix with the powder. c. Mix BMP solution with BCP or plus autogenic / allograft and apply into the recipient site. d. Cover the defect area using a barrier membrane or suture natural soft tissue without membrane. Product Code Particle Dose Particle Size Product Code Particle Dose Particle Size Product Code Particle...

7. Study Result on COWELL® BMP In Vivo Study Control group 4 weeks after surgery 8 weeks after surgery a. Inject distilled water into vial with lyophilized rhBMP-2 power in it and mix with the powder. b. Aspirate the mixture using a syringe. Jung-Bo Huh, et al., Alveolar ridge augmentation using anodized implants coated with Escherichia coli-derived recombinant human bone morphogenetic protein 2 (Beagle dog). - Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011. Histologic Findings : Tissue specimen collected approximately four months after the maxillary sinus grafting (human) • New bone...

Calcium Phosphate , Synthetic Bone Graft A porosity for new bone ingrowth • The porosity promotes ingrowth of osteoblast, osteoclast and growth factors. Osteoconductive resorbable synthetic bone graft material • INNO-CaP is a osteoconductive synthetic resorbable bone graft material consisting of Calcium Phosphate. Particle surface SEM image • INNO-CaP is completely resorpted and progressively replaced by normal-structured bone in the healing period. Excellent Biocompatibility and Conductivity • The characteristic biocompatibility and conductivity of the INNO-CaP represent the most safety....

INNO OSS & INNO OSS Allo Allograft FDBA, Cortical 50% Cancellous 50% Bovine Bone Substitute A Bone 100% fused to Natural Human Bone • Fast blood penetration. Product Features • Great hydrophilicity. • 3-Dimensional structure. • This product is made up of human tissue from trusted donors whose gender, age, and medical history were checked to ensure that their tissue could be used safely. • Maximizes bone fusion. • It is an ideal combination of 50% cortical powder and 50% cancellous powder for bone induction. r • Mutually connected porous structure. • The 50% cortical powder maintains the...

MEGA DERM™ PLUS Acellular Dermal Matrix MEGA DERM PLUS three-dimensional structure of the dermis Product Features • This product can carry out the functional blocks of the membrane (soft tissue penetration protection) due to its long absorption period, and has excellent manipulability. • Unlike other imported complete products, this product is produced under the stringent standards of the FDA in Korea. • The world's first E-Beam sterilization can induce safe and prompt Normal skin Other product • E-Beam is safe and can be effectively sterilized without destroying the collagen tissue...

Biodegradable Atelocollagen Membrane InnoGenic™ Non-resorbable Membrane InnoGenic™ Wifi-Mesh and InnoGenic™ PTFE-Mesh GTR(Guided Tissue Regeneration) GBR(Guided Bone Regeneration) membrane • Diaderm® is a dental membrane used for GTR (Guided Tissue Regeneration) and GBR (Guided Bone Regeneration) operation. • Diaderm® helps restoration of alveolar bone and protect operation site from infiltration of an epithelial cell and exterior circumstances. • The InnoGenic™ Wif i-Mesh, PTFE-Mesh and Ti-Mesh are non-resorbable barrier membrane to be applied over intraoral defects, especially, tooth...

Comparison to other similar products sold in market Clinical Case using the Wifi-Mesh InnoGenic™ Wifi-Mesh & PTFE-Mesh Bacterial infection at exposure Bacterial toxin penetration between filters at 50 μm intervals Bacterial toxin penetration between filters at 2 μm intervals No Bacterial toxin penetration thanks to non porous structure Instant Removal Safe for more than 6 weeks Shielding Function against Fiber Cell Extremely High Shape-keeping Capability against External Force Large Deformation Shrinkable Deformation • Periodontitis with local osteomyelitis of #45 & 47 • Bone graft using...