Singderm Monophasic Dermal Filler Introduction SD001
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® Singderm Perfect Monophasic HA Filler for Full Face Rejuvenation Hangzhou Singclean Medical Products Co., Ltd.

01 Singderm® Introduction 02 Treatment with Singderm® 03 Why Singderm® Is the Best Choice 04 Global Market 05 Singclean Filler Family

PART 01 Singderm® Introduction

01 Singderm® Honors China HA Filler lnnovative Brand & China Most Loved HA Filler Brand

02 Singderm® Overview Singderm® is a CE Approved monophasic hyaluronic acid dermal filler with lidocaine • Singderm®, being animal-origin free, consists of modfied hyaluronic acid (HA) produced by bacteria, formulated to a concentration of 24 mg/ml and 0.3% lidocaine in a physiologic buffer, presented in a pre-filled, disposable BD syringe. • Indicated for injection into the mid to deep dermis or subcutaneous for correction of mid or deep depressions of the skin, as well as for correcting age-related volume deficit. Certification: CE, NMPA, ISO13485, ISO

03 Singderm® Outstanding Features Effective Produced by SingLink® unique patented cross-linking technology to obtain a high viscosity smooth, uniform gel, helps achieve a natural looking Add 0. 3% lidocaine, creating more comfortable and painless experience Excellent biocompatibility, slower degradation rate, effectiveness rate is 92.7% at 12 month

04 Singderm® Development History Singderm® research project started 2015 Publication on the first issue of the Chinese edition of Third party inspection report obtained Clinic trails finished 2016 SingLink®patented cross-linking technology realized Aesthetic Surgery Journal Oct. 2020 Cooperate with National University of Singapore to promote the development of aesthetics industry

Raw Material Reliable HA Raw Material Singclean's non-animal origin HA is JP (Japanese Pharmacopoeia)or EP (European Pharmacopoeia) approved

SingLink® Technology SingLink®, Unique Patented Cross-linking Technology Form mono-phasic, smooth and homogeneous gel, contain no particles, soft texture without foreign body sensation

Dialysis Safety Test Report Test Items The gel should be transparent and free of foreign Qualified matter Protein Content Crosslinking Agent Residue The data comes from clinical and internal test data reports With U.S. Polymer Cellulose Dialysis Membrane efficiently elute residual cross-linking agent and other impurities

Filling German Advanced Inova Aseptic Filling Machine to prevent pollution and ensure production capacity

Sterilization Sweden's Up-To-Date Getinge Sterilizer for Terminal Sterilization to reach the 10-6 sterility assurance level and guarantee safety

PART 02 Treatment with Singderm®

Singderm® Indication Aimed at Full Face Rejuvenation Temple Nose Nasolabial folds Lip volume Jawline sculpting Marionette Lines Chin remodeling

PART 03 Why Singderm® Is the Best Choice

Reason 1 Competitive Advantages

•Singderm® is obtained by bio-fermentation, having good biocompatibility • Osmotic pressure and pH value are close to the human bo

Pure Gel Without Particles Monophasic Dermal Filler fits seamlessly with the surrounding tissue, bring natural beauty After injection, Singderm®’s shape is more stable and it is not easy to be dispersed by shear force, making gel hard to shift and spread

High Elasticity Strong Support Singderm® is excelling in retaining its shape when a force is applied, perfect for contouring and shaping With SingLink® technology, Singderm® has a more stable three-dimensional structure, ideal for maintaining long-term strong support and treating dep

Having Smaller Surface Area subject to enzymatic hydrolysis, maximally prolongs the enzymatic hydrolysis

SingLink® Cross-linking Technology creates a three- dimensional network structure, stable and long lasting

Long-lasting The actual concentration of cross-linked HA was measured by the filter paper filtration method Content mg/ml High Concentration of Cross-linked HA to achieve good filling and lifting effect

Comfortable Experience 0.3% Lidocaine • Slowly release after injection • Long-term pain relief (3-5h) Sharp Needle • BD/Terumo sharp needle to make injection less painful • Giving better experience of slight pain or even no

Comparison Between DVS And BDDE Comparison options DVS Divinyl Sulfone, C4H6O2S BDDE Butanediol Diglycidyl Ether, C10H18O4 Chemical reaction rate Fast Intramolecular and intermolecular crosslinking Reactions at the level of several vinyl groups with the formation of a high level of internal and intermolecular crosslinking A more detected molecular cross-linking The distance between the HA chains after crosslinking Close distance between molecules, tighter connection, greater product stability Greater distance between molecules in the chain Cross Link Level The reaction level is up to 99%....

Smooth Delivery An Innovative Glass Pre-fillable Syringe BD Hylok™ Designed for the Administration of Hyaluronic Acid

Comparison One hour later One hour later Other brands Other brands Singderm Singderm® Compared with traditional biphasic hyaluronic acid, Singderm® monophasic dermal filler has stronger support. Singderm® monophasic dermal filler has better cohesion, better viscosity, stable structure, and is hard to shift and spread.

Reason 2 Excellent Clinical Performance

Singderm® Effectiveness Rate •The efficacy rate is measured by wrinkle severity rating scale(WSRS) from baseline. •This clinical trial being a self-controlled study was performed in three clinical sites, 100 subjects participated. Singderm® effectiveness rate is 92.7% at 12 month while currently the highest 12-month effectiveness rate of the internationally well-known dermal filler is 8

Pain Score  Singderm® shows to be safe and painless. The median score of pain was 2.0 equivalent to benchmark.  no adverse events repor

Reason 3 Positive Clinical Feedback

Singderm® Before and After

Singderm® Before and After Before Nonsurgical Rhinoplasty Jawline Refining