ABDOMINAL ORGAN PERFUSION SYSTEMS
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ABDOMINAL ORGAN PERFUSION SYSTEMS - 1

Abdominal Organ PERFUSION SYSTEMS Liver • Kidney • Mesenteric Bed Intraluminal Vessel Perfusion www.hugo-sachs.de www.harvardapparatus.com

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ABDOMINAL ORGAN PERFUSION SYSTEMS - 2

PERFUSION & TISSUE BATH SYSTEMS OVERVIEW Solutions for All Aspects of Animal Physiology Research Organs Smooth Muscle GASTROINTESTINAL TRACT • • • • Esophagus Stomach Liver/Pancreas Intestine Systems for Organs/Applications • Moist Chamber—perfusion of liver, pancreas • UP-100—perfusion of liver ex vivo or in situ • PBTO—intraluminal intestine perfusion • CP—perfusion of GI organs and tissues using S peristaltic pump • IPR—perfusion of ileum peristaltic reflexes UROGENITAL TRACT • Kidney • Placenta VASCULAR MUSCULATURE • Hind Quarter • Mesenteric Bed • Coronary Vasculature • Moist...

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ABDOMINAL ORGAN PERFUSION SYSTEMS - 3

Abdominal ORGAN PERFUSION S Y S T E M S Hugo Sachs Elektronik (HSE), part of the Harvard Bioscience family of companies, provides top-notch, fully integrated physiology research systems, including perfusion and tissue bath systems for many organ and tissue types. This catalog contains all the information you need to choose an optimal isolated abdominal organ system for your research. These comprehensive and complete systems are modular in design, providing the flexibility to tailor a system to fit your specific needs. Whether you need a complete isolated organ system or an addition to a...

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ABDOMINAL ORGAN PERFUSION SYSTEMS - 4

CONFIGURING AN ISOLATED PERFUSED ORGAN SYSTEM Typical setup of complete Autoclavable Moist Chamber System rgans within the body are designed to perform different, specialized functions that work in unison to maintain homeostasis in a living organism. Despite their differences, similar conditions are required to study organs in isolation. These requirements include controlled temperature, a nutrient or buffer at physiological pH, aeration for the buffer, a perfusion pump to move the buffer and a system with a chamber to hold the isolated organ. Some organs may require additional equipment...

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ABDOMINAL ORGAN PERFUSION SYSTEMS - 5

Perfusion Pressure Perfusion Flow Portal Vein Roller Pump Transducer Amplifier Module Waste Perfusate is pumped from the reservoir into the portal vein or hepatic artery (not shown) using an analog peristaltic (roller) pump. A windkessel is installed in order to dampen the roller pump’s pulsations. Perfusion pressure and perfusion flow can be adjusted and are measured. Constant flow and constant pressure perfusion can be performed by the Servo Controller (SCP). A pressure transducer (P) together with the TAM-D constantly monitors the perfusion pressure. The perfusion flow is calculated from...

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ABDOMINAL ORGAN PERFUSION SYSTEMS - 6

KIDNEY PERFUSION VIA RENAL ARTERY Data Acquisition Dissolved Oxygen Dissolved Carbon Dioxide Renal artery Renal vein Ureter Windkessel Perfusion Pressure Transducer Amplifier Module Perfusion Flow Roller Pump Perfusate is pumped from the reservoir into the renal artery using an analog peristaltic (roller) pump. A windkessel is installed in order to dampen the roller pump’s pulsations. Perfusion pressure and perfusion flow are kept constant by the Servo Controller (SCP). A pressure transducer (P) together with the TAM-D constantly monitors the perfusion pressure. The perfusion flow is...

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ABDOMINAL ORGAN PERFUSION SYSTEMS - 7

Moist Chamber Features & Benefits • Superior temperature control of perfusate and organ • Precise positioning of cannulae and measurement probes • Compact and easy to use • Compatible with a variety of accessories, making it suitable for a wide range of applications • Provides a complete perfusion system when combined with the UP-100 or a perfusion control system Applications • Rodent isolated organ perfusion-liver, kidney, pancreas, mesenteric bed • Investigation of the tone of small blood vessels under the effect of vasoactive substances • Biochemistry-studying metabolic processes • Drug...

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ABDOMINAL ORGAN PERFUSION SYSTEMS - 8

Base Systems Autoclavable Moist Chamber Features & Benefits • Interchangeable connecting parts for the 16 openings around the chamber allows you to customize the chamber to suit your needs • Built-in bubble trap • Optional perfusate reservoir and oxygenator • Multiple cannulae sizes available to suit a variety of applications • Each perfusion line is equipped with an independent heat exchanger Applications • Long term drug studies on ex vivo liver, kidney, and other abdominal organs • Regenerative tissue engineering studies involving decellularization and recellularization with stem...

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ABDOMINAL ORGAN PERFUSION SYSTEMS - 9

Moist Chamber with Edema Balance Features & Benefits • Dual perfusion system-vascular and intraluminal intestinal • Built-in balance for edema evaluation and organ weight measurement Applications • Rodent isolated intestine perfusion • Microvascular permeability studies • Simultaneous study of vascular, luminal and lymphatic flows • Arterial, venous and intraluminal pressures and bowel weight • Septic multi-organ failure studies in gastrointestinal area This system is comprised of a moist chamber with a built-in organ weighing system. The jacketed chamber maintains a warm and moist...

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ABDOMINAL ORGAN PERFUSION SYSTEMS - 10

Universal Perfusion System (UP-100) Features & Benefits • Multipurpose system for perfusing isolated organs ex vivo or in situ • Ideal for perfusing isolated organs such as: liver, rabbit ear, heart, kidney, rat hind limb, mesenteric bed • Allows for constant flow or constant pressure perfusion Applications • Ex vivo perfusion of liver, kidney, mesenteric bed (requires the addition of a moist chamber) • Test of vasodilative drugs • Studying metabolic processes • Neural vascular tone • Organ preservation for transplant • In situ perfusion of liver, kidney, mesenteric bed, hind limb,...

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ABDOMINAL ORGAN PERFUSION SYSTEMS - 11

Operating Tables for In Situ Perfusion Studies Features & Benefits • Heated and homeothermic versions available • Includes paw holders • Capable of receiving thorax retractors and mounting ball joint holders Applications • For in situ perfusion studies, when paired with the UP-100 Universal Perfusion System • For general surgical work on small animals There are three heated options available for this operating table: • Basic Fixed Temperature: includes an adapter box and power supply. The temperature is fixed at 38°C. • Bdvanced Fixed Temperature: includes heating controller. Allows the...

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