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Antioxidants
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A COMPREHENSIVE RANGE OF ANTIOXIDANT TESTING KITS

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GLUTATHIONE PEROXIDASE GLUTATHIONE REDUCTASE SUPEROXIDE DISMUTASE TOTAL ANTIOXIDANT STATUS SOLUBLE TRANSFERRIN RECEPTOR (STFR) TOTAL IRON BINDING CAPACITY URIC ACID ORDERING INFORMATION GLOBAL DIAGNOSTIC SOLUTIONS PROVIDER NP NICHE PRODUCT When you see this symbol you will know that Randox have one of the only automated biochemistry assays available on the market UF UNIQUE FEATURE When you see this symbol you will know that this feature is unique to the Randox product

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BENEFITS OF RANDOX REAGENTS Randox offers an extensive range of third party diagnostic A wide range of formats and methods are available reagents which are internationally recognised as being of providing greater flexibility and choice for any laboratory size. the highest quality; producing accurate and precise results. In addition to flexible pack sizes and a comprehensive list We have an extensive test menu of more than 100 of analyser applications, we can also provide dedicated assays, covering over 100 disease markers including reagent packs (Randox Easy Read and Easy Fit reagents)...

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Antioxidants A Comprehensive Range of Antioxidant Testing Kits What are antioxidants? » An antioxidant is a molecule that prevents oxidation occurring in other molecules » Antioxidants can be present as vitamins in food, polyphenols in wine or even enzymes in the body » Oxidative stress and inflammation associated with it are the cause of most human illnesses » Free radicals produced by oxidation are groups of very reactive molecules that can interrupt important cellular processes » Antioxidants function to protect cells against free radical damage Why test antioxidants clinically? Testing...

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Glutathione Peroxidase Glutathione peroxidase is a family of enzymes designed to protect the body against oxidative damage. They are scavenging antioxidants and work by cleansing the free radicals that have formed in the body. • Harmful effects of selenium deficiency include an increased risk of recurrent miscarriage, muscular degeneration and male infertility. Measuring glutathione peroxidase allows the analysis of selenium levels as glutathione peroxidase correlates well with selenium. Selenium is a very important trace mineral. It supports the immune system and thyroid function and acts...

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Glutathione Reductase Glutathione reductase (GR) is an enzyme found in red blood cells. It helps to protect cells against the effects of oxidative stress. It is an extremely important antioxidant. It is so widespread that it can interact with free radicals in every single cell. Applications Clinical • Testing of glutathione reductase deficiency – a rare genetic disease. Clinical manifestations of this deficiency are very similar to that of G-6-PDH deficiency. There are two forms: – Reduced Glutathione – Oxidised Glutathione Glutathione reductase works with G-6-PDH to relieve oxidative...

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Superoxide Dismutase Superoxide dismutase is one of the body’s primary internal antioxidant defences, and plays a critical role in reducing the oxidative stress implicated in atherosclerosis and other life-threatening diseases. Superoxide dismutase catalyses the dismutation of superoxide into oxygen and hydrogen peroxide. Superoxide is one of the most dangerous free radicals present in the human body and by destroying it, the superoxide dismutase is performing a vital function. Superoxide dismutase is involved in lipid peroxidation (the process in which free radicals steal an electron from...

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Total Antioxidant Status (TAS) NP TAS is the measurement of non-quantitative antioxidant function. Considering the total level of antioxidants in the human body, provides a good overall view of antioxidants in a single measurement and can provide more relevant information to individually measure components. Total antioxidant measurement considers the cumulative effect of all antioxidants present. Measuring TAS takes into account reactions between antioxidants and contributions from unknown factors or components that are not normally recognised as antioxidants from the diet. Applications...

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ASSOCIATED PRODUCTS BY RANDOX Albumin Albumin is the most abundant protein in serum representing 55-65% of the total protein. Its main biological functions are to maintain the water balance in serum and plasma and to transport and store a wide variety of ligands e.g. fatty acids, calcium, bilirubin and hormones such as thyroxine. Recent evidence suggests albumin may exert antioxidant properties by functioning as a serum peroxidase in the presence of reduced glutathione. Low albumin levels (Hypoalbuminaemia) have been associated with liver disease, kidney disease, intestinal disease,...

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Ferritin Ferritin is a protein which contains iron and acts as the primary source of stored cellular iron. The basic isoferritins are present in the liver, spleen and bone marrow and are concerned mainly with the long-term storage of iron while the acidic isoferritins are found in the placenta, tumour tissues and myocardium. Ferritin contributes to the body’s antioxidant defence by sequestering iron and preventing it from catalyzing the production of free radicals in the cell. Randox Ferritin • Latex enhanced immunoturbidimetric • Liquid ready-to-use reagents for convenience and ease-of-use...

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Total Iron Binding Capacity (TIBC) Total Iron Binding Capacity (TIBC) measures the blood’s capacity to bind iron with transferrin and is therefore an indirect measurement of transferrin. As previously mentioned, iron is capable of stimulating the production of harmful free radicals. Randox TIBC • Colorimetric method • Liquid ready-to-use reagents for convenience and ease of use • Stable to expiry date when stored at +2 to +80C • Applications available detailing instrument-specific settings for a wide range of clinical chemistry analysers • Measuring range of 57.7-672 µg/dl Uric Acid Uric...

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