LCMS-8050
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Liquid Chromatograph Mass Spectrometer

Sensitivity Beyond Comparison Continuing the evolution of Shimadzu's UF technology, Shimadzu introduces the LCMS-8050 triple quadrupole mass spectrometer, offering unparalleled measurement speeds and high-sensitivity performance. High-sensitivity quantitation delivered at high speed Multi-component analysis performed more rapidly Simultaneous qualitative and quantitative analyses The high performance of the LCMS-8050 defies expectations, redefining high-sensitivity, high-speed analysis.

Experience a New Realm of High-Sensitivity & High-Speed Performance UFsensitivity™ Combining Speed and High Sensitivity High-Sensitivity & High-Speed Positive/Negative Ionization Switching in 5 msec A Case Study Using High-Speed Positive/Negative Ionization Switching High-speed polarity switching has a high impact on LC-MS/MS method design and capability by optimizing the signal response for each target compound resulting in a single injection analysis cycle, faster rates of sample throughput and a greater number of target compounds in a single method. High-speed polarity switching pushes...

High-Sensitivity & High-Speed Scanning at 30,000 u/sec Simultaneous Quantitative and Qualitative Analysis Simultaneous High-Speed Screening of 12 Toxicological Drugs The LCMS-8050 is capable of simultaneously obtaining both qualitative and quantitative information in a single analysis. Acquisition occurs so rapidly that MS/MS scans and MRM measurements can be performed concurrently while maintaining quantitative accuracy. MS/MS scans are usable and reliable because even at 30,000 u/sec, Shimadzu uses a 0.1 u scan step. Maintains a high-quality spectrum even at the world’s fastest scanning...

UFsensitivity High Sensitivity for Trace Quantitative Analysis Scientists who demand trace-level quantitation will benefit from a newly designed heated ESI probe and a new high-efficiency CID cell, the UFsweeper™ III. These technological improvements combined with Shimadzu’s patented ion optics system deliver robust high-sensitivity performance.

UFsensitivity UFswitching In order to improve desolvation efficiency, the newly developed heated ESI probe combines a high-temperature gas with the nebulizer spray, assisting in the desolvation of large droplets and facilitating ionization. This development allows for high-sensitivity analysis of a wide range of target compounds. 289.05 > 97.10 *The transmission of heat to the LC line has been minimized by mounting the heaters in the bottom-most position. Heating gas ON Signal intensity: 30 X improvement Excellent Reproducibility Even at Attogram (ag) Levels Both sensitivity and...

UFswitching Polarity Switching Technology with No Compromise in Quality or Sensitivity Ultra-high speed positive/negative ionization switching technology [ UFswitching ] maintains constant data quality and sensitivity with no loss of quantitative accuracy. Laboratories can now use a single method for both positive and negative ions, increasing sample throughput and saving method development time.

Only 5 msec to Achieve Stable Quantitative Accuracy with Positive/Negative Ionization Switching Ion intensity is maintained even when performing polarity switching at ultra-high speed. The LCMS-8050 uses unique high-voltage power supply technology to achieve an ultra-high-speed positive/negative ionization switching time of just 5 msec. The LCMS-8050 is also the only instrument of its type to maintain ion intensity even when performing polarity switching at ultra-high speed, yielding consistent, reproducible data. Excellent quantitative results can be obtained from UHPLC peaks no more than...

UFscanning Simultaneous, Highly Reliable Quantitative and Qualitative Analysis With the development of a unique approach to ultra-high-speed scan technology [UFscanning], the LCMS-8050 maintains spectrum quality and ion intensity at any scan speed. Perform quantitative and qualitative analysis simultaneously with a maximum high-speed scan rate of 30,000 u/sec.

UFsensitivity UFswitching Maintain Sensitivity and Mass Accuracy Even at 30,000 u/sec Greater ion transmission at any scan speed has been achieved by precisely controlling the voltage applied to the quadrupoles across the mass scale. As Shimadzu quadrupole technology using a data collection interval of 0.1 u high quality mass spectra are acquired without loss of sensitivity or mass accuracy. Top of peak is not defined resulting in a large variation in the m/z determination. Proper data collection rate allows accurate determination of m/z value. Variation in m/z Caused by Different Sampling...

UF Technologies Combine Sensitivity and High Speed The LCMS-8050 combines the following technologies to ensure highly sensitive, high-speed performance: [ UFsensitivity ] achieves high-sensitivity performance utilizing a new heated ESI probe and new UFsweeper III collision cell. [ UFswitching ] high-speed positive/negative ionization switching and high-speed MRM [ UF-MRM ] maintain data quality and sensitivity. [ UFscanning ] high-speed scan rate obtains high-quality mass spectra, even during high-speed analysis. Heated ESI Probe High-temperature gas supplements the nebulizer gas, improving...

UFsweeper III Collision Cell A high-sensitivity, high-speed collision cell, the proprietary UFsweeper III accelerates ions out of the collision cell without loss of momentum. Achieving fast sweeping on successive scans, it offers twice the CID efficiency of UFsweeper II, maintains signal intensity, and suppresses crosstalk, even for high-speed or simultaneous multi-component analysis. UFsensitivity UFswitching UF-MRM UFsweeper III high-speed ion transport technology minimizes ion loss even at a dwell time of 0.8 msec. High-speed MRM transitions up to 555 MRMs/sec accelerate laboratory...

Engineered for Robustness and Easy Operation/Maintenance Maintains High Sensitivity Even During Successive Demanding Analyses In addition to speed and sensitivity, Shimadzu designed the LCMS-8050 for robustness to meet the most demanding laboratory requirements and most difficult matrices. The figure below plots the area results from 1000 consecutive analyses of a deproteinized blood plasma sample spiked with alprazolam. The LCMS-8050 achieves excellent reproducibility with a 4.59 % RSD for the area results over the 1000 analyses. 50 pg/mL alprazolam in plasma m/z 309.05 > 281.15 Area % RSD...