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EML4 -ALK Fusion Gene Detection Kit

EML4 -ALK Fusion Gene Detection Kit
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Human EML4 -ALK Gene Fusion Detection Kit (Real-Time PCR assay) ALK GENE FUSION IN LUNG CANCER ALK is an anaplastic lymphoma kinase. The ALK gene encodes a transmembrane tyrosine kinase receptor . ALK gene rearrangement is a driving mutation underlying the development of NSCLC. EML4 is the most common ALK fusion partner. ALK gene rearrangement has been identified in 5–6% of NSCLC case. In 2017, the NCCN clinical practice guidelines clearly stated that ALK gene testing is necessary before treating NSCLC. Crizotinib is an effective targeted drug for treating ALK-positive NSCLC, which was approved by the US FDA in 2011. Clin Cancer Res. 2014 March 1; 20(5): 1204–1211 Crizotinib has shown significant benefits in the management of ALK positive NSCLC compared to conventional chemotherapy. FDA-approved drugs Crizotinib DETECTED GENES COSMIC ID Mutation Type Reaction Tube Mutation Type Reaction Tube

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PRODUCT INFORMATION Product Name Pack Size Instruments Validated Sample Type Human EML4 -ALK Gene Fusion Detection Kit Tumor tissue, Pleural and ascites DETECTION SIGNIFICANCE Qualitative detection of EML4-ALK gene fusion mutation in RNA samples is performed to evaluate the degree of benefit from ALK tyrosine kinase inhibitors (TKIs). This helps to assist clinicians in more comprehensively selecting NSCLC patients who may benefit from crizotinib, and is applicable to NSCLC patients before entering targeted therapy, providing a scientific basis for individualized treatment of cancer...

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EML4 -ALK Fusion Gene Detection Kit
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