ACQUITY UPLC H-Class PLUS Bio
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UPLC- PLUS UPLC- PLUS ACQUITY UPLC H-Class PLUS Bio FOR YOUR MOST CHALLENGING BIOSEPARATIONS Waters THE SCIENCE OF WHAT’S POSSIBLE."

PURPOSE BUILT TO CHARACTERIZE THE COMPLEX Increasing complexity of modern biotherapeutic characterization, monitoring, and quality control assays require even more demanding analytical techniques to accurately define and assess critical quality control attributes (CQAs) related to product safety, stability, and efficacy. The ACQUITY™ UPLC™ H-Class PLUS Bio System provides the same high resolution, high sensitivity separations you have come to expect from UPLC Technology, with the flexibility and ruggedness to run all the chromatography modes you require – ion exchange (IEX), size exclusion...

HIGHEST RESOLUTION OF ANY BIO-INERT QUATERNARY LC SYSTEM Low dispersion Wide range of detection capabilities UPLC-optimized detectors to match your application needs, including photodiode array, UV/Vis, fluorescence, refractive index, evaporative light scattering, and mass detection. Flexible sample support Accepts either vials or ANSI well plate formats. Extend capacity for high throughput and open access environments with the optional Sample Organizer. Fraction collection Analytical scale, temperature controlled fraction collection from your high efficiency UPLC separations to enable...

A BETTER PERSPECTIVE FOR YOUR BIOSEPARATIONS Leverage the benefits of UPLC Technology to improve your HPLC methods. By scaling your bioseparations methods to UPLC, your assays will benefit from the combination of increased speed, resolution, and sensitivity that comes with modern small particle chemistries. Purpose built for biopharmaceutical 0.12 characterization, the ACQUITY UPLC H-Class PLUS Bio System leverages high resolution column technology, advanced increase the information you receive from detection, and intelligent informatics to each and every sample. With exceptional quaternary...

RELIABLE OPERATION UNDER DEMANDING CONDITIONS Assays utilizing IEX, SEC, and HIC modes of chromatography typically utilize high ionic strength mobile phases containing denaturing agents. The ACQUITY UPLC H-Class PLUS Bio System’s bio-inert flow path is made of non-stainless steel and iron-free materials to minimize undesirable protein interactions and maximize system robustness. The result: a system that is ideally suited for routine, trouble-free operation with maximum recovery of biomolecules and consistently high system performance. Hydrophobic interaction chromatography separation of...

ON-DEMAND MOBILE PHASE CREATION The bioQuaternary Solvent Manager (bioQSM) automatically blends mobile phase combinations and gradients on demand, enabling you to obtain the optimum retention and selectivity requirements for your analysis. Designed with bio-inert materials, the bioQSM accommodates the aqueous, high ionic strength mobile phases and organic solvents used in biopharmaceutical applications. Auto•Blend Plus Technology automatically blends your mobile phase to a specified pH and ionic strength or organic modifier percentage, for an infinite set of analytical conditions. By...

ACCELERATE YOUR PRODUCTIVITY Adopting a proven analytical technology that improves laboratory efficiency is advantageous for supporting your new projects and products. Designed to support your HPLC, UHPLC, and UPLC methods, the ACQUITY UPLC H-Class PLUS Bio System is the ideal solution to address legacy methods, while enabling the transition to true UPLC performance when you are ready. ■■ Reproduce established HPLC methods while enabling seamless transfer to UPLC Faster methods development with expanded solvent and column capacity and fully scalable column chemistries 2 ACQUITY UPLC H-Class...

For your local sales office, please visit www.waters.com/contact Waters THE SCIENCE OF WHAT’S POSSIBLE.™ Waters, The Science of What's Possible, Alliance, ACQUITY, Auto^Blend Plus, eCord, Rapi Fluor-MS, UPLC, and XBridge are trademarks of Waters Corporation. All other trademarks are the property of their respective owners. ©2018 Waters Corporation. Printed in the U.S.A. April 2018 720005992EN LM-SIG